INT215331

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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.73
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Anatomy Link Frequency
proximal 1
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 74.40 Quite High
addiction 21 67.28 Quite High
fluoxetine 14 56.56 Quite High
Pyramidal cell 30 29.68 Quite Low
long-term potentiation 126 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Hippocampus 20 5.00 Very Low Very Low Very Low
potassium channel 12 5.00 Very Low Very Low Very Low
Action potential 10 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 105 99.32 Very High Very High Very High
Neurodegenerative Disease 35 94.16 High High
Disease 41 92.16 High High
Death 77 82.04 Quite High
Targeted Disruption 9 45.28 Quite Low
Stress 7 19.92 Low Low
Dementia 7 5.24 Low Low
Cognitive Disorder 14 5.00 Very Low Very Low Very Low
Tremor 7 5.00 Very Low Very Low Very Low
Neuroblastoma 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We find that TBP occupancy at the promoter of upregulated genes was elevated irrespective of the presence of the TATA box.
Positive_regulation (upregulated) of TBP
1) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.42 Pain Relevance 0
Promoter occupancy of TBP was higher in 59Q TBP transfected cells compared to N3 and 16QTBP transfected cells at the Vdac1 and Actb promoters (Fig. 4).
Positive_regulation (occupancy) of TBP
2) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.07 Pain Relevance 0
Using an artificially tethered TBP with promoter-reporter fusions and at the genome-wide level it has been shown that many gene specific transcription factors exert their effects by directly or indirectly interacting with TBP and stabilizing TBP-TATA box interaction at the proximal promoter region [13], [14].
Positive_regulation (stabilizing) of TBP in proximal
3) Confidence 0.48 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.05 Pain Relevance 0.12
Chromatin Immunoprecipitation studies at a TATA containing and a TATA less promoter from the differentially expressed genes suggested that TBP occupancy was elevated in vivo.
Positive_regulation (elevated) of TBP
4) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.50 Pain Relevance 0
Besides, SCA17, caused by the expansion of polyQ tract in the TATA binding protein itself, normal TBP is also found in intra nuclear protein aggregates formed in other neurodegenerative diseases, notably, huntington's disease [8].
Positive_regulation (caused) of SCA17 associated with disease and neurodegenerative disease
5) Confidence 0.44 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.69 Pain Relevance 0
The upregulation of genes in 16Q TBP may be a consequence of higher total levels of functional TBP resulting from expression of the endogenous as well as the transfected gene.
Positive_regulation (upregulation) of TBP
6) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
Further, human TBP gene was amplified from the p-15b16QTBP and p-15b59QTBP for re-cloning into pEGFPN3 vector (Clontech).
Positive_regulation (amplified) of TBP
7) Confidence 0.39 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
The depolarization and increase in input resistance caused by the activation of M1 receptors could also enhance NMDAR activation during synaptic transmission and in particular during TBP.
Positive_regulation (activation) of TBP
8) Confidence 0.22 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.07
To assess the component of the EPSP mediated by NMDARs during TBP, we gave five presynaptic stimuli at 100 Hz and compared the resulting EPSP waveform in the presence and absence of 50 ?
Positive_regulation (mediated) of TBP
9) Confidence 0.21 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.07

General Comments

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