INT2155

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 111
Total Number 113
Disease Relevance 16.58
Pain Relevance 77.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
spinal cord 9
neurons 5
pituitary 3
dorsal horn 3
neuronal 3
Sst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 678 100.00 Very High Very High Very High
Enkephalin 124 100.00 Very High Very High Very High
substance P 117 100.00 Very High Very High Very High
Spinal cord 75 100.00 Very High Very High Very High
Neuropeptide 59 100.00 Very High Very High Very High
Neurotransmitter 23 100.00 Very High Very High Very High
Dynorphin 11 100.00 Very High Very High Very High
Antinociceptive 11 99.98 Very High Very High Very High
Root ganglion neuron 6 99.98 Very High Very High Very High
ganglionectomy 6 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 30 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 38 99.90 Very High Very High Very High
Ganglion Cysts 20 99.82 Very High Very High Very High
Intellectual Impairment 1 99.80 Very High Very High Very High
Ulcers 26 99.76 Very High Very High Very High
Injury 8 99.74 Very High Very High Very High
Urological Neuroanatomy 25 99.68 Very High Very High Very High
Hypertension 32 99.56 Very High Very High Very High
Duodenal Ulcer 6 99.56 Very High Very High Very High
Immunization 3 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin nerve terminals were reduced, and aminergic fibers and serotonin were enhanced after both acute and chronic mechanical compressions.
Negative_regulation (reduced) of Somatostatin in nerve associated with somatostatin and serotonin
1) Confidence 0.59 Published 1992 Journal Spine Section Abstract Doc Link 1373525 Disease Relevance 0.16 Pain Relevance 0.58
Immunohistochemical studies on rats showed cysteamine to deplete immunoreactive somatostatin, but not substance P, in the substantia gelatinosa of the spinal trigeminal nucleus and spinal cord.
Negative_regulation (deplete) of somatostatin in spinal cord associated with substantia gelatinosa, somatostatin, spinal cord and substance p
2) Confidence 0.59 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6209149 Disease Relevance 0.33 Pain Relevance 0.90
In all of the structures examined, particularly the dorsal roots, a roughly parallel decrease of substance P and somatostatin was found with capsaicin dose.
Negative_regulation (decrease) of somatostatin in dorsal roots associated with qutenza, somatostatin and substance p
3) Confidence 0.59 Published 1983 Journal J. Neurosci. Section Abstract Doc Link 6185658 Disease Relevance 0 Pain Relevance 1.21
Such injury drastically reduces content of the nociceptive peptides, substance P, and somatostatin in the dorsal horn of the spinal cord and dorsal root ganglia innervating the limb.
Negative_regulation (reduces) of somatostatin in dorsal horn associated with nociception, injury, dorsal horn, somatostatin, spinal cord and substance p
4) Confidence 0.59 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15246843 Disease Relevance 0.63 Pain Relevance 0.58
Because the ulcerogenic properties of cysteamine are markedly reduced by treatment with somatostatin, we considered the possibility that cysteamine-induced duodenal ulcer might be mediated by depletion of tissue somatostatin, and thereby of its paracrine influences on gastrin and gastric acid secretion.
Negative_regulation (depletion) of somatostatin associated with duodenal ulcer and somatostatin
5) Confidence 0.58 Published 1981 Journal Endocrinology Section Abstract Doc Link 6118261 Disease Relevance 0.19 Pain Relevance 0.29
Dorsal root ganglionectomy decreased somatostatin levels in the dorsal cord, supporting the previously proposed role for this peptide as a primary sensory neurotransmitter or modulator; but somatostatin content also was decreased both rostral and caudal to spinal transection, indicating the presence of ascending and descending somatostatin pathways within the spinal cord.
Negative_regulation (decreased) of somatostatin in spinal cord associated with neurotransmitter, somatostatin, ganglionectomy and spinal cord
6) Confidence 0.58 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6174691 Disease Relevance 0 Pain Relevance 0.80
Dorsal root ganglionectomy decreased somatostatin levels in the dorsal cord, supporting the previously proposed role for this peptide as a primary sensory neurotransmitter or modulator; but somatostatin content also was decreased both rostral and caudal to spinal transection, indicating the presence of ascending and descending somatostatin pathways within the spinal cord.
Negative_regulation (decreased) of somatostatin in spinal cord associated with neurotransmitter, somatostatin, ganglionectomy and spinal cord
7) Confidence 0.58 Published 1982 Journal J. Neurochem. Section Abstract Doc Link 6174691 Disease Relevance 0 Pain Relevance 0.96
Both SKF 38393 and quinpirole, when given alone, tended to decrease the haloperidol-induced increase in somatostatin levels; when both D1 and D2 agonists were administered together, somatostatin levels declined significantly.
Negative_regulation (declined) of somatostatin associated with agonist and somatostatin
8) Confidence 0.58 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883854 Disease Relevance 0 Pain Relevance 0.86
The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.
Negative_regulation (decrease) of somatostatin in cardiac muscle associated with somatostatin
9) Confidence 0.57 Published 1993 Journal Int. J. Cardiol. Section Abstract Doc Link 8349385 Disease Relevance 0.33 Pain Relevance 0.29
In chronically implanted awake animals, the perforant path population spike was increased 1 h after cysteamine but returned to the predrug level by 24 h when somatostatin seemed to be depleted.
Negative_regulation (depleted) of somatostatin in spike associated with somatostatin
10) Confidence 0.57 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7907266 Disease Relevance 0 Pain Relevance 0.25
Rimorphin also inhibited glucose-induced insulin secretion even in the cysteamine-treated rat pancreas from which somatostatin had been depleted.
Negative_regulation (depleted) of somatostatin in pancreas associated with somatostatin
11) Confidence 0.57 Published 1986 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 2877510 Disease Relevance 0 Pain Relevance 0.47
To test for a functional interaction between these two pathways, we examined the effects of cysteamine, which enhances somatostatin release for a few hours after administration but produces subsequent depletion of somatostatin lasting several days, on perforant path evoked potentials recorded in the dentate gyrus.
Negative_regulation (depletion) of somatostatin in dentate gyrus associated with somatostatin
12) Confidence 0.57 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7907266 Disease Relevance 0.09 Pain Relevance 0.14
In addition, we found a down-regulation of somatostatin (SOM) in DRG and spinal dorsal horn after expression of GFRalpha-1 was knocked down, which suggested the possible relationship between the anti-hyperalgesic effect of GDNF and GFRalpha-1 on neuropathic pain and endogenous SOM.
Negative_regulation (regulation) of somatostatin in dorsal horn associated with ganglion cysts, hyperalgesia, spinal dorsal horn, neuropathic pain and somatostatin
13) Confidence 0.57 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16289634 Disease Relevance 1.44 Pain Relevance 1.07
The enhanced GH response to morphine observed in DEX-PVN implanted rats might be due to a decreased somatostatin tone.
Negative_regulation (decreased) of somatostatin associated with somatostatin, dexamethasone and morphine
14) Confidence 0.57 Published 1991 Journal Brain Res. Section Abstract Doc Link 1664769 Disease Relevance 0.06 Pain Relevance 1.14
Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei.
Negative_regulation (reduced) of somatostatin associated with somatostatin and substance p
15) Confidence 0.57 Published 1983 Journal Peptides Section Abstract Doc Link 6197700 Disease Relevance 0 Pain Relevance 0.42
We found that tonic release of somatostatin was reduced by 76% in the presence of tetrodotoxin (TTX) and was regulated by endogenous secretion of glutamate and GABA.
Negative_regulation (reduced) of somatostatin associated with tetrodotoxin, gaba, glutamate and somatostatin
16) Confidence 0.56 Published 1992 Journal Endocrinology Section Abstract Doc Link 1346378 Disease Relevance 0 Pain Relevance 1.17
This suggests that the intrinsic pancreatic neurons responsible for the inhibitory effect of somatostatin are peptidergic.
Negative_regulation (effect) of somatostatin in neurons associated with somatostatin
17) Confidence 0.56 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1698248 Disease Relevance 0 Pain Relevance 0.51
Blockade of axonal neuronal transmission by tetrodotoxin (10(-7) mol/L) completely abolished the inhibitory effect of somatostatin (992 +/- 53 U/30 min).
Negative_regulation (effect) of somatostatin in neuronal associated with tetrodotoxin and somatostatin
18) Confidence 0.56 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 1698248 Disease Relevance 0 Pain Relevance 0.49
The somatostatin response to ANP was unaffected by the axonal blocker tetrodotoxin but abolished by addition of the selective NPR-A antagonist, anantin.
Neg (unaffected) Negative_regulation (unaffected) of somatostatin associated with tetrodotoxin, antagonist and somatostatin
19) Confidence 0.56 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.16 Pain Relevance 0.58
Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus.
Negative_regulation (blockade) of somatostatin in posterior associated with nociception, nociceptor and somatostatin
20) Confidence 0.55 Published 2005 Journal Pain Section Title Doc Link 16043293 Disease Relevance 0.32 Pain Relevance 0.93

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