INT215570

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2ry14) signal transducer activity (P2ry14)
P2ry14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 3 97.44 Very High Very High Very High
agonist 31 97.12 Very High Very High Very High
Brush evoked pain 4 78.00 Quite High
Peripheral nerve injury 1 66.08 Quite High
Acute pain 1 62.72 Quite High
adenocard 25 53.60 Quite High
Neurotransmitter 37 50.00 Quite Low
Spinal cord 9 48.40 Quite Low
Inflammation 25 42.24 Quite Low
Hippocampus 14 41.28 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 6 78.00 Quite High
Nervous System Injury 4 76.08 Quite High
Targeted Disruption 6 67.24 Quite High
Pain 3 62.72 Quite High
INFLAMMATION 27 42.24 Quite Low
Necrosis 2 39.80 Quite Low
Cancer 2 39.44 Quite Low
Neurological Disease 3 13.44 Low Low
Bordatella Infection 14 5.00 Very Low Very Low Very Low
Ganglion Cysts 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The P2Y14 receptor is activated by various UDP sugars, but not by adenine or uridine nucleotides [8, 19].
Neg (not) Positive_regulation (activated) of P2Y14
1) Confidence 0.30 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0 Pain Relevance 0.42
LPS increased P2Y6 and P2Y14, decreased P2X7 and left P2Y1 and P2Y2,4 receptor activity unchanged.
Positive_regulation (increased) of P2Y14
2) Confidence 0.28 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096663 Disease Relevance 0.41 Pain Relevance 0.28
P2Y receptors are basically activated by adenine and uridine nucleotides, such as ATP, ADP, uridine diphosphate (UDP), and uridine triphosphate (UTP), but not by nucleosides and they are classified according to their sensitivity to purines and/or pyrimidines: P2Y1, 12 and P2Y13 are adenine nucleotide-preferring receptors; P2Y6 is preferred by uridine nucleotides; P2Y2, 4 and P2Y11 are receptors with mixed selectivity; whereas P2Y14 is activated by UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-glucuronic acid [83].
Positive_regulation (activated) of P2Y14
3) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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