INT21560

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 30
Total Number 39
Disease Relevance 7.16
Pain Relevance 32.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cord 4
cell groups 2
brain 2
pituitary 2
DRG 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 1671 100.00 Very High Very High Very High
mu opioid receptor 408 100.00 Very High Very High Very High
Opioid 314 100.00 Very High Very High Very High
Morphine 612 99.98 Very High Very High Very High
Inflammation 27 99.98 Very High Very High Very High
agonist 51 99.96 Very High Very High Very High
Endogenous opioid 18 99.92 Very High Very High Very High
Physical dependence 4 99.84 Very High Very High Very High
withdrawal 9 99.68 Very High Very High Very High
opiate 8 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 23 99.98 Very High Very High Very High
Drug Dependence 18 99.84 Very High Very High Very High
Neuroblastoma 3 99.84 Very High Very High Very High
Lordosis 21 99.56 Very High Very High Very High
Targeted Disruption 32 98.32 Very High Very High Very High
Stress 7 97.96 Very High Very High Very High
Inflammatory Pain 3 92.68 High High
Pain 13 92.56 High High
Asthma 6 89.00 High High
Substance Withdrawal Syndrome 1 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR).
Neg (little) Positive_regulation (inducing) of muOR Neg (little) Binding (internalization) of associated with analgesic, mu opioid receptor, tolerance and morphine
1) Confidence 0.50 Published 2006 Journal Neuroscience Section Abstract Doc Link 16887280 Disease Relevance 0 Pain Relevance 0.56
Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR).
Neg (little) Positive_regulation (inducing) of mu opioid receptor Neg (little) Binding (internalization) of associated with analgesic, mu opioid receptor, tolerance and morphine
2) Confidence 0.50 Published 2006 Journal Neuroscience Section Abstract Doc Link 16887280 Disease Relevance 0 Pain Relevance 0.55
These results demonstrate that the integrity of muOR is necessary for CFA-induced changes in deltaOR trafficking to occur and suggest that these changes could be elicited by stimulation of muOR by endogenous opioids released in response to chronic inflammatory pain.
Positive_regulation (necessary) of muOR Binding (integrity) of associated with ipn and endogenous opioid
3) Confidence 0.49 Published 2004 Journal Pain Section Abstract Doc Link 15157687 Disease Relevance 0.60 Pain Relevance 0.64
The results of the present experiments indicate that ERalpha is required for estrogen-induced MOR internalization and suggest that ERalpha can mediate rapid actions of estrogen.
Positive_regulation (required) of MOR Binding (internalization) of associated with opioid receptor
4) Confidence 0.45 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.34 Pain Relevance 0.58
Estrogen induces internalization of MOR in cell groups of the limbic-hypothalamic lordosis-regulating circuit.
Positive_regulation (induces) of MOR Binding (internalization) of in cell groups associated with opioid receptor and lordosis
5) Confidence 0.45 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.31 Pain Relevance 0.67
The results of the present experiments indicate that ERalpha is required for estrogen-induced MOR internalization and suggest that ERalpha can mediate rapid actions of estrogen.
Positive_regulation (estrogen-induced) of MOR Binding (internalization) of associated with opioid receptor
6) Confidence 0.45 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605406 Disease Relevance 0.34 Pain Relevance 0.52
Further studies are warranted to examine the relationship of muOR availability with BUP therapeutic actions, and the clinical implications of increased muOR binding during withdrawal.
Positive_regulation (increased) of muOR Binding (binding) of associated with withdrawal and buprenorphine
7) Confidence 0.44 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10942856 Disease Relevance 0 Pain Relevance 0.82
Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.
Positive_regulation (estrogen-induced) of mu-opioid receptor Binding (internalization) of associated with opioid receptor
8) Confidence 0.40 Published 2003 Journal J. Neurosci. Res. Section Title Doc Link 12605406 Disease Relevance 0.38 Pain Relevance 0.79
Estrogen receptor-alpha is required for estrogen-induced mu-opioid receptor internalization.
Positive_regulation (required) of mu-opioid receptor Binding (internalization) of associated with opioid receptor
9) Confidence 0.40 Published 2003 Journal J. Neurosci. Res. Section Title Doc Link 12605406 Disease Relevance 0.38 Pain Relevance 0.79
The hypothalamic-pituitary-adrenal (HPA) axis is activated by opioids under stressful conditions through binding to mu-opioid receptors (MOR).
Positive_regulation (activated) of MOR Binding (binding) of in pituitary associated with mu opioid receptor and opioid
10) Confidence 0.37 Published 2010 Journal Rinsho Byori Section Abstract Doc Link 20408448 Disease Relevance 1.56 Pain Relevance 0.72
A persisting challenge is to elucidate those neurochemical parameters modulated by long-term morphine treatment that facilitate MOR-Galpha(s) association.
Positive_regulation (facilitate) of MOR Binding (association) of associated with opioid receptor and morphine
11) Confidence 0.34 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17576791 Disease Relevance 0 Pain Relevance 0.74
Long-term morphine treatment decreases Galpha(s) phosphorylation, which is a key mechanism underlying the previously demonstrated increased association of MOR and Galpha(s) in opioid tolerant tissue.
Positive_regulation (increased) of MOR Binding (association) of associated with opioid receptor, opioid and morphine
12) Confidence 0.34 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17576791 Disease Relevance 0 Pain Relevance 0.79
This study demonstrates that 1) Galpha(s) exists as a phosphoprotein, 2) the stoichiometry of Galpha(s) phosphorylation decreases after long-term morphine treatment, and 3) in vitro dephosphorylation of Galpha(s) increases its association with MOR.
Positive_regulation (increases) of MOR Binding (association) of associated with opioid receptor and morphine
13) Confidence 0.29 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17576791 Disease Relevance 0 Pain Relevance 0.84
Initial cross-linking experiments indicated the absolute requirement of the high-affinity (125)I-beta-endorphin binding to the mu-opioid receptor prior to the appearance of the low molecular weight species, suggesting that the 22-kDa protein could be a degraded fragment of the receptor.
Positive_regulation (requirement) of mu-opioid receptor Binding (binding) of associated with opioid receptor
14) Confidence 0.26 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10854259 Disease Relevance 0.09 Pain Relevance 0.24
Estrogen treatment of ovariectomized rats induces MOR internalization, providing a neurochemical signature of estrogen activation of the medial preoptic nucleus.
Positive_regulation (induces) of MOR Binding (internalization) of in medial preoptic nucleus associated with opioid receptor
15) Confidence 0.25 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466444 Disease Relevance 0.09 Pain Relevance 0.68
Progestin reversed estrogen-induced MOR internalization, suggesting that progesterone blocked estrogen-induced endogenous opioid release, relieving estrogen inhibition and facilitating lordosis.
Positive_regulation (estrogen-induced) of MOR Binding (internalization) of associated with endogenous opioid, opioid receptor and lordosis
16) Confidence 0.25 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11466444 Disease Relevance 0.33 Pain Relevance 0.98
Our results indicate that morphine application appears to cause a redistribution of GPR177 from cytosol to the cell surface and enhanced MOR/GPR177 complex formation at the cell periphery.
Positive_regulation (cause) of MOR Binding (formation) of associated with opioid receptor and morphine
17) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 0.98
To examine the effect of opioid agonists on the MOR/GPR177 interaction in greater detail, we used coimmunoprecipitation to investigate whether opioid treatment promotes MOR/GPR177 complex formation.
Spec (whether) Positive_regulation (promotes) of MOR Binding (formation) of associated with mu agonist, opioid receptor and opioid
18) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.38
This redistribution permits enhanced MOR/GPR177 complex formation at the cell periphery.
Positive_regulation (enhanced) of MOR Binding (formation) of associated with opioid receptor
19) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.13
Deletion of PKCgamma had no significant effect on the mRNA product of spinal mu-opioid receptors but caused an increase of maximal binding of the mu-opioid receptor agonist [3H][d-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin in spinal cord membranes obtained from PKCgamma knockout mice.
Positive_regulation (increase) of mu-opioid receptor Binding (binding) of in spinal cord associated with targeted disruption, agonist, mu opioid receptor, enkephalin, opioid receptor and spinal cord
20) Confidence 0.22 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11278552 Disease Relevance 0.36 Pain Relevance 1.00

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