INT215752

Context Info Confidence 0.06 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.86 Pain Relevance 0.57

cytosol (Prf1) endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) molecular_function (Prf1)

Prf1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neurotransmitter 12 99.48 Glutamate 9 95.52 gABA 4 94.52 ischemia 9 88.24 adenocard 12 85.84 Hippocampus 13 85.60 Central nervous system 13 76.00 Inflammation 4 71.20 cytokine 3 70.16 Inflammatory response 1 69.88

Disease Link Frequency Relevance Heat Hypoxia 7 97.84 Cv Unclassified Under Development 8 88.24 Brain Injury 1 71.36 INFLAMMATION 5 71.20 Necrosis 1 67.96 Cancer 3 67.60 Stress 2 6.96 Neurodegenerative Disease 13 5.00 Disease 11 5.00 Embryonal Carcinoma 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, the actions of these neurotransmitters become evident only when activation of P1 receptors is impaired, suggesting a critical role for this receptor during hypoxic events.

Negative_regulation (impaired) of Positive_regulation (activation) of P1 associated with neurotransmitter and hypoxia

1) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.86 Pain Relevance 0.57

General Comments

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