INT215850
From wiki-pain
(Difference between revisions)
Latest revision as of 16:46, 21 September 2012
| Context
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Info
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| Confidence
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0.50
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| First Reported
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2007
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| Last Reported
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2010
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| Negated
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0
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| Speculated
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2
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| Reported most in
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Body
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| Documents
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5
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| Total Number
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7
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| Disease Relevance
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6.15
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| Pain Relevance
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0.25
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| Anatomy Link
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Frequency
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| retina
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2
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[edit] Sentences Mentioned In
| Key:
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Protein
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Mutation
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Event
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Anatomy
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Negation
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Speculation
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Pain term
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Disease term
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| To further clarify the participation of ER stress, we examined the changes in BiP and CHOP in the retina after NMDA-induced injury.
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| Collectively, the above results indicate that NMDA can cause ER stress in the retina, and that the neurotoxicity induced by NMDA is due in part to a mechanism dependent on CHOP protein induction through excessive ER stress.
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| (active form) may remain to translate BiP and CHOP mRNAs to proteins.
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| Consequently, ATF4 and CHOP have been considered to be prime targets of PERK-mediated regulation in vivo [7].
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| Since CHOP is a member of the CCAAT/enhancer-binding protein family that is induced by ER stress and participates in ER-mediated apoptosis, CHOP may be a key molecule in retinal cell death [17].
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| Regulation (participates) of CHOP associated with stress, apoptosis and death
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| Next, we investigated the distribution and time-course of changes in GRP78/BiP and CHOP, a proapoptosis protein, after NMDA injection.
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| The mRNA of the transcription factor CHOP, which is involved in cell division and apoptosis in response to stress, is regulated by ARE [187].
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