INT215880

Context Info Confidence 0.09 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.08

unfolded protein binding (Hspa5) lyase activity (Car2) endoplasmic reticulum (Hspa5) response to stress (Hspa5) cytoplasm (Car2) cytosol (Car2)

Car2 (Mus musculus) Hspa5 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 6 79.16 Inflammatory response 12 5.00 Chronic pancreatitis 2 5.00 tolerance 1 5.00 Cholecystokinin 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Necrosis 6 81.28 INFLAMMATION 18 79.16 Pancreatitis 22 78.64 Death 52 76.88 Disease 1 70.68 Apoptosis 28 40.32 Stress 36 39.60 Frailty 22 5.00 Targeted Disruption 12 5.00 Diabetes Mellitus 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PERK's activity is dynamically regulated by association/disassociation of the ER chaperone protein BiP/GRP78, whose activity is regulated by Ca2+ as a cofactor and by ATP as a substrate.

Ca2 Regulation (regulated) of BiP

1) Confidence 0.09 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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