INT215883

Context Info Confidence 0.00 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.80 Pain Relevance 0.06

endoplasmic reticulum (Eif2ak3) translation (Eif2ak3) kinase activity (Eif2ak3) cell (Eif2ak3) response to stress (Eif2ak3) cytoplasm (Eif2ak3)

Anatomy Link Frequency acinar cells 1 Eif2ak3 (Mus musculus) Musd1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 6 57.28 Inflammatory response 12 5.00 Chronic pancreatitis 2 5.00 tolerance 1 5.00 Cholecystokinin 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Necrosis 6 94.08 Death 52 86.40 Apoptosis 28 77.76 INFLAMMATION 18 57.28 Pancreatitis 22 56.76 Disease 1 48.80 Stress 36 17.72 Frailty 22 5.00 Targeted Disruption 12 5.00 Diabetes Mellitus 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We speculate that activation of PERK through normal secretory activity results in PERK-dependent regulation of anti-oncotic or pro-survival factors that maintain the viability of the acinar cells at adult stages.

PERK-dependent Regulation (regulation) of pro-survival in acinar cells

1) Confidence 0.00 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 0.80 Pain Relevance 0.06

General Comments

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