INT215900

Context Info Confidence 0.42 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.65 Pain Relevance 0.42

cell adhesion (Mcam) plasma membrane (Mcam)

Anatomy Link Frequency endothelial cells 4 endothelia 2 Mcam (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 120 99.84 Inflammation 12 74.48 Central nervous system 30 60.32 Inflammatory response 3 53.76 Multiple sclerosis 9 5.00 anesthesia 9 5.00 isoflurane 3 5.00 medulla 3 5.00

Disease Link Frequency Relevance Heat Disease 138 97.56 Motor Neuron Diseases 108 96.60 Nerve Degeneration 18 81.20 INFLAMMATION 15 74.48 Pathologic Processes 3 71.44 Stroke 6 70.88 Death 6 67.52 Cerebral Edema 9 65.28 Targeted Disruption 9 46.16 Congenital Anomalies 9 36.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Additionally, downregulation of Glut-1 and CD146 expressions in the endothelial cells of the BSCB may be related to altered endothelial lining leading to vascular leakage.

Negative_regulation (downregulation) of Gene_expression (expressions) of CD146 in endothelial cells

1) Confidence 0.42 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.68 Pain Relevance 0.13

Another of our findings was that endothelia surrounding capillaries were partially revealed by CD146 antigen expression in the cervical and lumbar spinal cords of G93A mice at initial and, more markedly, at late stages of disease.

Negative_regulation (revealed) of Gene_expression (expression) of CD146 in endothelia associated with disease

2) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.72 Pain Relevance 0.14

Downregulation of Glut-1 and CD146 expressions in spinal cord endothelial cells was also found in G93A mice at early and late stage disease and may relate to altered endothelial lining leading to vascular leakage.

Negative_regulation (Downregulation) of Gene_expression (expressions) of CD146 in endothelial cells associated with disease and spinal cord

3) Confidence 0.41 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.25 Pain Relevance 0.15

General Comments

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