INT215941

Context Info Confidence 0.58 First Reported 2007 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 7.00 Pain Relevance 1.40

peptidase activity (MMP25) extracellular region (MMP25) proteinaceous extracellular matrix (MMP25) plasma membrane (MMP25)

Anatomy Link Frequency colon 2 leukocytes 1 neutrophils 1 MMP25 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 66 99.24 metalloproteinase 249 97.88 Spinal cord 9 88.72 Central nervous system 30 81.64 chemokine 18 61.84 cytokine 18 59.84 Inflammatory mediators 1 37.24 rheumatoid arthritis 28 26.00 Multiple sclerosis 19 5.00 Pain 12 5.00

Disease Link Frequency Relevance Heat Cancer 157 99.84 Glioma 8 99.68 Colon Cancer 16 99.28 INFLAMMATION 67 99.24 Disease Progression 8 99.24 Prostate Cancer 4 97.24 Metastasis 36 95.80 Adenocarcinoma 4 92.08 Ovarian Cancer 4 88.24 Breast Cancer 24 85.16

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP-25 is also known as leukolysin and is expressed by neutrophils [26,33].

Gene_expression (expressed) of leukolysin in neutrophils

1) Confidence 0.58 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.38 Pain Relevance 0.39

There is an excellent review on the properties and expression of MMP-17 and MMP-25 in cancer published by Sohail and coworkers [57].

Gene_expression (expression) of MMP-25 associated with cancer

2) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.68 Pain Relevance 0.22

Human MMP-25 is expressed by leukocytes and neutrophils, and in colon, urothelial, brain, and prostate cancers [59, 119–122].

Gene_expression (expressed) of MMP-25 in colon associated with prostate cancer

3) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.75 Pain Relevance 0.19

Expression of MMP-25 in HCT-116 human colon cancer cells promotes tumorigenesis in nude mice.

Gene_expression (Expression) of MMP-25 in colon associated with colon cancer

4) Confidence 0.27 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.58 Pain Relevance 0.25

Strong MMP-25 staining was detected in inflammatory-like cells consistent with the known expression of MMP-25 in leukocytes [64]. 6.3.

Gene_expression (expression) of MMP-25 in leukocytes associated with inflammation

5) Confidence 0.21 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.61 Pain Relevance 0.35

General Comments

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