INT216043

Context Info Confidence 0.15 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.82 Pain Relevance 0.30

plasma membrane (Rtn4r, Lingo1) endoplasmic reticulum (Rtn4r)

Rtn4r (Mus musculus) Lingo1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 10 83.12 Eae 14 5.00 depression 8 5.00 amygdala 4 5.00 nMDA receptor 4 5.00 Hippocampus 4 5.00 withdrawal 2 5.00 Catechol-O-methyltransferase 2 5.00 Pain threshold 2 5.00 antidepressant 2 5.00

Disease Link Frequency Relevance Heat Cancer 2 99.48 Necrosis 2 99.24 Injury 6 75.28 Disease 22 68.36 Schizophrenia 124 50.00 Heart Defects 2 36.88 Digeorge Syndrome 2 32.56 Cognitive Disorder 16 27.20 Congenital Anomalies 8 9.60 Anxiety Disorder 28 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RTN4R, a glycosylphosphatidylinositol-linked (GPI-linked) cell surface molecule, forms a heteromeric receptor complex with either LINGO-1 and p75, or LINGO-1 and TROY (a tumor necrosis factor (TNF) receptor family member).

RTN4R Binding (complex) of LINGO-1 associated with necrosis and cancer

1) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.41 Pain Relevance 0.15

RTN4R, a glycosylphosphatidylinositol-linked (GPI-linked) cell surface molecule, forms a heteromeric receptor complex with either LINGO-1 and p75, or LINGO-1 and TROY (a tumor necrosis factor (TNF) receptor family member).

RTN4R Binding (complex) of LINGO-1 associated with necrosis and cancer

2) Confidence 0.15 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077930 Disease Relevance 0.41 Pain Relevance 0.15

General Comments

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