INT21610

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 13.28
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANGPT2) signal transduction (ANGPT2) extracellular space (ANGPT2)
extracellular region (ANGPT2) plasma membrane (ANGPT2) nucleus (ANGPT2)
Anatomy Link Frequency
plasma 2
colon 1
midbrain 1
body 1
ANGPT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 25 99.82 Very High Very High Very High
COX2 2 99.46 Very High Very High Very High
midbrain 4 99.08 Very High Very High Very High
alcohol 13 99.00 Very High Very High Very High
Inflammation 191 98.80 Very High Very High Very High
Dopamine 17 98.72 Very High Very High Very High
rheumatoid arthritis 71 97.20 Very High Very High Very High
Angina 10 96.44 Very High Very High Very High
Catecholamine 18 95.96 Very High Very High Very High
Central nervous system 9 93.88 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 38 99.90 Very High Very High Very High
Inflammatory Breast Neoplasms 268 99.84 Very High Very High Very High
Sepsis 266 99.84 Very High Very High Very High
Sickle Cell Anemia 12 99.60 Very High Very High Very High
INFLAMMATION 193 98.80 Very High Very High Very High
Alkalosis 1 98.76 Very High Very High Very High
Hypertension 102 98.32 Very High Very High Very High
Hyperemia 48 98.24 Very High Very High Very High
Syndrome 23 98.08 Very High Very High Very High
Increased Venous Pressure Under Development 24 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified several angiogenesis-related genes (namely VEGF, TBXA2R, PTGS2/COX2, THBD/thrombomodulin, and ANGPT2/angiopoietin 2) that were upregulated in IBC.
Positive_regulation (upregulated) of ANGPT2 associated with inflammatory breast neoplasms and cox2
1) Confidence 0.41 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.44 Pain Relevance 0.08
The other 20 upregulated genes encoded growth factors (VEGF, DTR/HB-EGF, IGFBP7, IL-6, ANGPT2, EREG, CCL3/MIP1A, and CCL5/RANTES) or growth factor receptors (TBXA2R, TNFRSF10A/ TRAILR1, and ROBO2), mainly involved in angiogenesis.
Positive_regulation (upregulated) of ANGPT2
2) Confidence 0.41 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.14 Pain Relevance 0.08
Bartter's syndrome is a rare disorder characterized by normal or low arterial blood pressure (BP), despite marked elevation in plasma renin activity, angiotensin II (Ang-II), and aldosterone, along with hypokalemic metabolic alkalosis.
Positive_regulation (elevation) of Ang-II in plasma associated with alkalosis and syndrome
3) Confidence 0.38 Published 1993 Journal J Clin Anesth Section Abstract Doc Link 8373612 Disease Relevance 0.59 Pain Relevance 0.28
Although we did identify a relationship between arterial hypotension and circulating Ang II after the first day of severe sepsis, the modest statistical significance and lack of a similar relationship between hypotension and PRA (a biologic precursor to Ang II) temper our enthusiasm to declare arterial pressure a dominant factor leading to persistent RAS activation during sepsis.
Positive_regulation (circulating) of Ang II associated with pressure volume 2 under development and sepsis
4) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.32 Pain Relevance 0.06
At the same time that plasma was sampled for PRA and Ang II, we assessed the microvascular response to reactive hyperemia using NIRS.
Positive_regulation (sampled) of Ang II in plasma associated with hyperemia
5) Confidence 0.25 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.19 Pain Relevance 0.09
We note that the levels of PRA and Ang II measured in our septic subjects are elevated nearly two-fold compared to outpatients with risk factors for vascular disease [33,34], arguing that the acute septic state contributes to RAS activation.
Positive_regulation (elevated) of Ang II associated with increased venous pressure under development
6) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 1.07 Pain Relevance 0.03
After 24 hours of resuscitation to clinically-defined endpoints of preload and arterial pressure, Ang II and PRA were elevated in septic subjects and the degree of elevation correlated negatively with the rate of microvascular reoxygenation during reactive hyperemia.
Positive_regulation (elevated) of Ang II associated with hyperemia
7) Confidence 0.23 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2875539 Disease Relevance 0.81 Pain Relevance 0.04
Because Ang II was equally elevated in patients who did or did not receive exogenous vasoconstrictors, we are urged to investigate relationships between circulating RAS mediators and microvascular function in sepsis.
Positive_regulation (elevated) of Ang II associated with sepsis
8) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.40 Pain Relevance 0.09
Circulating Ang II was also increased in sepsis subjects (median 47.2 pg/mL, range 3.7 to 146 pg/mL) at this early timepoint (control median 10.6 pg/mL, range 2.8 to 17 pg/mL; see Figure 1, Panel B).
Positive_regulation (increased) of Ang II associated with sepsis
9) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2875539 Disease Relevance 0.32 Pain Relevance 0
During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients.
Positive_regulation (increased) of Ang-2 associated with pain
10) Confidence 0.18 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16803577 Disease Relevance 0.49 Pain Relevance 0.10
These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels.
Positive_regulation (elevated) of Ang-2 associated with sickle cell anemia
11) Confidence 0.18 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16803577 Disease Relevance 0.55 Pain Relevance 0.09
In the asymptomatic phase, serum Ang-2 (P < 0.001), EPO (P < 0.001) and sTIE2 (P = 0.03) were elevated in patients.
Positive_regulation (elevated) of Ang-2
12) Confidence 0.13 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16803577 Disease Relevance 0.51 Pain Relevance 0.10
In contrast, 160 mg valsartan increased PRA and Ang II levels within 4 and 6 hours of dosing, respectively, and they were still higher than placebo at 24 and 48 hours (P < 0.05).
Positive_regulation (increased) of Ang II
13) Confidence 0.12 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 0.06 Pain Relevance 0
In the rat, treatments that increase the numbers of Hes3 cells (Dll4, Ang2, insulin) also rescue midbrain dopamine neurons from a lethal toxin, 6-hydroxy-dopamine (6OHDA).
Positive_regulation (increase) of Ang2 in midbrain associated with dopamine and midbrain
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.08 Pain Relevance 0.27
Similarly, the angiopoietins Ang1 and Ang2, and their cellular receptor Tie2, which are all widely expressed in RA synovitis, are regulated by both hypoxia and TNF-?
Positive_regulation (angiopoietins) of Ang2 associated with hypoxia, synovitis and rheumatoid arthritis
15) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.16 Pain Relevance 0.32
The ratio of plasma Ang 1 to Ang 2 levels is thought to be a measure of the body’s tendency toward VEGF-mediated angiogenesis.
Positive_regulation (ratio) of Ang 2 in body
16) Confidence 0.06 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.06 Pain Relevance 0
A study investigating the benign pathology of open and closed colon and rectal resection patients demonstrated that both surgical methods are associated with a decrease in Ang 1 and an increase in Ang 2 levels on PODs 1 and 3 such that a significantly greater Ang 1/Ang 2 ratio was noted at both time points.
Positive_regulation (increase) of Ang 2 in colon
17) Confidence 0.06 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.06 Pain Relevance 0
The TI fluctuation estimate, after relative to 'during', had increased by 50.3% after ACE/Ang II inhibition and had reduced by 22.2% after diuretic treatment (p = 0.1).
Positive_regulation (increased) of Ang II
18) Confidence 0.04 Published 2004 Journal Pharmacoepidemiol Drug Saf Section Body Doc Link 14971122 Disease Relevance 0 Pain Relevance 0
When this increase occurs during treatment with ACEIs and ARBs, the result is increased levels of PRA but during treatment with aliskiren, the effect of increased renin levels is blocked, so the levels of Ang I and Ang II, as well as PRA, are all reduced.52 The clinical trials do not report any major adverse effects of aliskiren compared with ARBs or ACEs being generally well tolerated by all patients.
Positive_regulation (increased) of Ang II
19) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922316 Disease Relevance 1.12 Pain Relevance 0.16
ACE inhibitors may reduce alcohol intake by elevating a nonapeptide fragment or by elevating central ANG II levels.
Positive_regulation (elevating) of ANG II associated with alcohol
20) Confidence 0.03 Published 1990 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 2178480 Disease Relevance 0.12 Pain Relevance 0.59

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