INT2162

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Context Info
Confidence 0.60
First Reported 1979
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 2.90
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) plasma membrane (Comt) cytoplasm (Comt)
Anatomy Link Frequency
plasma 2
cerebral cortex 2
basal ganglia 2
posterior 1
nucleus 1
Comt (Rattus norvegicus)
Comt - V158M (2)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 84 100.00 Very High Very High Very High
monoamine 28 100.00 Very High Very High Very High
Catecholamine 23 100.00 Very High Very High Very High
cerebral cortex 16 100.00 Very High Very High Very High
anesthesia 8 100.00 Very High Very High Very High
agonist 8 99.96 Very High Very High Very High
antagonist 4 99.44 Very High Very High Very High
fluoxetine 3 98.08 Very High Very High Very High
Dopamine 33 95.92 Very High Very High Very High
medulla 2 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Psychosis 4 98.92 Very High Very High Very High
Depression 60 97.28 Very High Very High Very High
Heart Disease 14 97.20 Very High Very High Very High
Manic Depressive Disorder 125 94.16 High High
Coronary Artery Disease 23 88.52 High High
Death 66 87.24 High High
Pain 3 82.40 Quite High
Anxiety Disorder 45 80.12 Quite High
Cv Unclassified Under Development 17 78.32 Quite High
Affective Disorder 5 70.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.
Regulation (effects) of catechol-O-methyl transferase in basal ganglia associated with cerebral cortex and monoamine
1) Confidence 0.60 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.22 Pain Relevance 0.54
The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.
Regulation (effects) of COMT in basal ganglia associated with cerebral cortex and monoamine
2) Confidence 0.60 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.22 Pain Relevance 0.57
Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients.
Regulation (effect) of catechol-O-methyltransferase (V158M) associated with catechol-o-methyltransferase, depression and fluoxetine
3) Confidence 0.44 Published 2009 Journal J Affect Disord Section Title Doc Link 18533273 Disease Relevance 0.10 Pain Relevance 0.33
Further stratification based on gender revealed an isolated effect of the COMT genotype in males (P=0.035) but not in females (P=0.650) in percent reduction in HAM-D(21) scores in the eighth week.
Regulation (effect) of COMT
4) Confidence 0.44 Published 2009 Journal J Affect Disord Section Body Doc Link 18533273 Disease Relevance 0 Pain Relevance 0
A substitution of valine (Val) by methionine (Met) at codon 158 affects the activity of the COMT enzyme, and individuals with the Val/Val genotype have a three- to fourfold higher activity of the COMT enzyme than those with Met/Met genotype [1].
Regulation (affects) of COMT enzyme associated with catechol-o-methyltransferase
5) Confidence 0.27 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1906749 Disease Relevance 0.29 Pain Relevance 0.36
In vitro modulation of COMT-catalyzed L-DOPA methylation by EGCG or crude tea extracts
Regulation (modulation) of COMT
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916818 Disease Relevance 0.06 Pain Relevance 0.12
A substitution of valine (Val) by methionine (Met) at codon 158 affects the activity of the COMT enzyme, and individuals with the Val/Val genotype have a 3–4-times higher enzyme activity than those with the Met/Met genotype [1].
Regulation (affects) of COMT enzyme associated with catechol-o-methyltransferase
7) Confidence 0.26 Published 2008 Journal BMC Psychiatry Section Body Doc Link PMC2453123 Disease Relevance 0.44 Pain Relevance 0.31
Theoretically, haplotypes of the COMT gene may influence COMT activity.
Regulation (influence) of COMT associated with catechol-o-methyltransferase
8) Confidence 0.24 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC1906749 Disease Relevance 0.53 Pain Relevance 0.34
The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.
Regulation (effects) of catechol-O-methyl transferase in cerebral cortex associated with cerebral cortex and monoamine
9) Confidence 0.20 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.22 Pain Relevance 0.54
The post-ischemic effects on cerebral cortex and basal ganglia monoamine levels and monoamine oxidase (MAO A and B) and catechol-O-methyl transferase (COMT) activities were evaluated in Mongolian gerbils (Meriones unguiculatus) subjected to bilateral common carotid arteries of occlusion for 15 min and reflow for 7 days.
Regulation (effects) of COMT in cerebral cortex associated with cerebral cortex and monoamine
10) Confidence 0.20 Published 1980 Journal Acta Neuropathol. Section Abstract Doc Link 7435143 Disease Relevance 0.22 Pain Relevance 0.57
In 2006, Dávila et al. [199] investigated the role of COMT Val158Met polymorphism on psychotic features in 42 BDI patients, further testing the hypothesis of a possible influence of this variant on blood plasma concentration of metabolites of dopamine and noradrenaline and on the severity of the disorder and the response to olanzapine and lithium.
Spec (investigated) Regulation (role) of COMT (V158M) in plasma associated with dopamine, psychosis and noradrenaline
11) Confidence 0.12 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.41 Pain Relevance 0.44
Influence of catecholamine receptor agonists and antagonists on the ultradian rhythm of the EEG in the posterior hypothalamus.
Regulation (Influence) of catecholamine receptor in posterior associated with anesthesia, antagonist, catecholamine and agonist
12) Confidence 0.08 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 9521490 Disease Relevance 0 Pain Relevance 0.55
Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata.
Regulation (Effect) of catecholamine-receptor in nucleus associated with medulla and catecholamine
13) Confidence 0.03 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 374097 Disease Relevance 0.18 Pain Relevance 0.45
This study examined the impact of a chronic physiological elevation of plasma cortisol levels on adrenal catecholamine synthetic enzyme and proenkephalin A mRNA expression in foetal sheep.
Spec (examined) Regulation (impact) of catecholamine synthetic enzyme in plasma associated with catecholamine
14) Confidence 0.00 Published 1999 Journal J. Neuroendocrinol. Section Abstract Doc Link 10444314 Disease Relevance 0 Pain Relevance 0.05

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