INT216283

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) extracellular region (Bdnf)
plasma membrane (Ephb1) cytoplasmic membrane-bounded vesicle (Bdnf) cytoplasm (Ephb1)
Bdnf (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 2 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 51 99.12 Very High Very High Very High
Injury 17 97.08 Very High Very High Very High
Apoptosis 22 50.00 Quite Low
Ganglion Cysts 8 50.00 Quite Low
Death 9 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Glaucoma 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Frailty 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF inhibited the activation of ERK (until 6 hours after hypoxia) and p38 (at 6 hours after hypoxia), while agmatine suppressed the activation of JNK (in significant amounts from 9 hours after hypoxia).


BDNF Negative_regulation (inhibited) of Positive_regulation (activation) of ERK associated with hypoxia
1) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2089075 Disease Relevance 0.99 Pain Relevance 0

General Comments

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