INT21661

Context Info Confidence 0.02 First Reported 1990 Last Reported 1990 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.26 Pain Relevance 0.60

mitochondrion (Gls2)

Anatomy Link Frequency brain 2 Gls2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opiate 6 100.00 tolerance 1 99.76 Physical dependence 1 99.42 Dextromethorphan 6 75.00 Opioid 2 66.72 Abstinence syndrome 1 41.44 nMDA receptor 2 25.00 addiction 1 25.00 antagonist 1 25.00

Disease Link Frequency Relevance Heat Drug Dependence 1 99.42 Disorders Of The Lacrimal System 1 57.12 Tremor 1 52.88 Appetite Loss 1 50.40 Pain 1 48.24 Akathisia 1 47.68 Sleep Disorders 1 46.56 Vomiting 2 45.76 Diarrhoea 1 45.12 Nicotine Addiction 2 42.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

According to the hypothesis that the development of physical dependence on and tolerance to opiates depends on the inhibition by opiates of L-asparaginase and L-glutaminase activities in the brain, and the blockade by opiates of the aspartatergic/glutamatergic receptors especially NMDA, four female and fourty-four male heroin addicts were included in a double-blind clinical trial.

Regulation (depends) of Negative_regulation (inhibition) of L-glutaminase in brain associated with physical dependence, tolerance and opiate

1) Confidence 0.02 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2187002 Disease Relevance 0.26 Pain Relevance 0.60

General Comments

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