INT21664

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Context Info
Confidence 0.02
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.26
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gls2)
Anatomy Link Frequency
brain 1
Gls2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 6 100.00 Very High Very High Very High
tolerance 1 99.46 Very High Very High Very High
Physical dependence 1 99.12 Very High Very High Very High
Dextromethorphan 6 75.00 Quite High
Opioid 2 66.72 Quite High
Abstinence syndrome 1 41.44 Quite Low
nMDA receptor 2 25.00 Low Low
addiction 1 25.00 Low Low
antagonist 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.12 Very High Very High Very High
Disorders Of The Lacrimal System 1 57.12 Quite High
Tremor 1 52.88 Quite High
Appetite Loss 1 50.40 Quite High
Pain 1 48.24 Quite Low
Akathisia 1 47.68 Quite Low
Sleep Disorders 1 46.56 Quite Low
Vomiting 2 45.76 Quite Low
Diarrhoea 1 45.12 Quite Low
Nicotine Addiction 2 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to the hypothesis that the development of physical dependence on and tolerance to opiates depends on the inhibition by opiates of L-asparaginase and L-glutaminase activities in the brain, and the blockade by opiates of the aspartatergic/glutamatergic receptors especially NMDA, four female and fourty-four male heroin addicts were included in a double-blind clinical trial.
Negative_regulation (inhibition) of L-glutaminase in brain associated with physical dependence, tolerance and opiate
1) Confidence 0.02 Published 1990 Journal Int J Clin Pharmacol Ther Toxicol Section Abstract Doc Link 2187002 Disease Relevance 0.26 Pain Relevance 0.60

General Comments

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