INT216936

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.59
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7) cell morphogenesis (P2rx7) mitochondrion organization (P2rx7)
protein complex (P2rx7) transmembrane transport (P2rx7) cytoplasm (P2rx7)
Anatomy Link Frequency
pore 2
P2rx7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 97 99.76 Very High Very High Very High
Inflammation 150 99.58 Very High Very High Very High
Nerve growth factor 4 92.76 High High
Hyperalgesia 12 89.36 High High
Inflammatory mediators 24 87.72 High High
Inflammatory response 24 86.08 High High
withdrawal 4 85.68 High High
Pain 64 84.12 Quite High
agonist 14 76.84 Quite High
rheumatoid arthritis 5 66.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 32 100.00 Very High Very High Very High
INFLAMMATION 204 99.58 Very High Very High Very High
Hyperalgesia 12 89.36 High High
Pain 64 84.12 Quite High
Neuropathic Pain 57 74.56 Quite High
Disease 33 68.48 Quite High
Rheumatoid Arthritis 5 66.72 Quite High
Hypersensitivity 16 61.80 Quite High
Nociception 4 58.56 Quite High
Pressure And Volume Under Development 1 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the lack of selective compounds, the development of the P2X7 receptor knockout mouse (P2X7 ????
Negative_regulation (development) of Gene_expression (knockout) of P2X7 receptor associated with targeted disruption
1) Confidence 0.42 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.96 Pain Relevance 0.60
and IL-10 being significantly attenuated in the P2X7 ????
Negative_regulation (attenuated) of Gene_expression (???) of P2X7
2) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.09 Pain Relevance 0.29
Interestingly, some studies have also demonstrated that release of the ‘anti-inflammatory–cytokine, IL-10, is impaired in P2X7????
Negative_regulation (impaired) of Gene_expression (???) of P2X7 associated with inflammation and cytokine
3) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.82 Pain Relevance 0.55
This study also demonstrated that the levels of cell-free IL-10 are significantly reduced in P2X7 ????
Negative_regulation (reduced) of Gene_expression (???) of P2X7
4) Confidence 0.37 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.47 Pain Relevance 0.22
P2X7R ion channel and large pore
Negative_regulation (pore) of Gene_expression (ion channel) of P2X7R in pore
5) Confidence 0.34 Published 2009 Journal Purinergic Signal Section Body Doc Link PMC2686830 Disease Relevance 0.24 Pain Relevance 0.18

General Comments

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