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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx7, Ryr1) cytoplasm (P2rx7, Ryr1) plasma membrane (P2rx7, Ryr1)
cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
Anatomy Link Frequency
sensory nerve 1
P2rx7 (Mus musculus)
Ryr1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 99.86 Very High Very High Very High
Pain 16 93.60 High High
Inflammatory mediators 6 90.72 High High
Nerve growth factor 1 85.56 High High
Inflammation 35 65.24 Quite High
antagonist 6 32.84 Quite Low
Inflammatory response 6 22.92 Low Low
rheumatoid arthritis 1 20.32 Low Low
Neuritis 1 15.84 Low Low
Eae 2 12.84 Low Low
Disease Link Frequency Relevance Heat
Pain 16 93.60 High High
INFLAMMATION 48 90.72 High High
Neuropathic Pain 14 65.88 Quite High
Targeted Disruption 8 42.04 Quite Low
Disease 8 38.00 Quite Low
Nervous System Injury 1 31.52 Quite Low
Rheumatoid Arthritis 1 20.32 Low Low
Neuritis 1 15.84 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The actions of the increasing number of cytokines whose release is modulated by the P2X7 receptor are better understood; in most cases these cytokines are potent sensitisers or activators of sensory nerve terminals (and thus contribute to the generation of pain signalling), and most also induce expression of further downstream inflammatory mediators, or enzyme capable of producing them (e.g., nitric oxide synthase, cyclooxygenase-2, superoxide products, nerve growth factor; Woolf et al. [33, 34]; Samad et al. [35]; Parvathenani et al. [36]).
P2X7 receptor Regulation (modulated) of release in sensory nerve associated with pain, inflammatory mediators, nerve growth factor and cytokine
1) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.55 Pain Relevance 0.52

General Comments

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