INT216945

Context Info Confidence 0.14 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0.12

protein complex (P2rx7, Casp1) cytoplasm (P2rx7, Casp1) cell death (P2rx7, Casp1) transport (P2rx7) cell morphogenesis (P2rx7) intracellular (Casp1)

Anatomy Link Frequency macrophages 3 P2rx7 (Mus musculus) Casp1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 35 90.68 cytokine 22 87.20 Pain 16 50.00 antagonist 6 39.68 tolerance 1 31.68 chemokine 1 29.40 Neuropathic pain 7 5.00 Inflammatory mediators 6 5.00 Inflammatory response 6 5.00 Arthritis 4 5.00

Disease Link Frequency Relevance Heat Disease 8 91.04 INFLAMMATION 48 90.68 Pain 16 50.00 Neuropathic Pain 14 5.00 Targeted Disruption 8 5.00 Arthritis 5 5.00 Hypersensitivity 4 5.00 Hyperalgesia 3 5.00 Apoptosis 2 5.00 Neuritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ATP-stimulation of P2X7 results in the rapid activation of caspase-1 in macrophages and the release of mature, biologically active, IL-1?

Positive_regulation (stimulation) of P2X7 in macrophages Positive_regulation (results) of Positive_regulation (activation) of caspase-1 in macrophages

1) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.18 Pain Relevance 0.12

General Comments

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