INT216977

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.93
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lpar4) signal transduction (Lpar4) plasma membrane (Lpar4)
signal transducer activity (Lpar4)
Anatomy Link Frequency
longitudinal muscle 1
leukocyte 1
neurons 1
neurite 1
ovary 1
Lpar4 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 65 99.68 Very High Very High Very High
Kinase C 37 95.12 Very High Very High Very High
cytokine 75 94.92 High High
adenocard 23 90.48 High High
antagonist 65 90.32 High High
qutenza 24 83.52 Quite High
Central nervous system 5 81.44 Quite High
medulla 1 79.40 Quite High
metalloproteinase 12 79.04 Quite High
cerebral cortex 4 78.48 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 69 99.68 Very High Very High Very High
Targeted Disruption 93 99.64 Very High Very High Very High
Neuroblastoma 3 97.48 Very High Very High Very High
Disease 37 95.60 Very High Very High Very High
Shock 3 95.24 Very High Very High Very High
Ovarian Cancer 49 93.88 High High
Aggression 6 92.64 High High
Bone Cancer 43 90.52 High High
Pressure And Volume Under Development 6 87.28 High High
Cancer 107 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The brain expresses relatively high levels of LPA4; and it has been shown, using heterologous expression in B103 neuroblastoma cells, to cause LPA-dependent growth cone collapse and neurite retraction through G12/13-RhoA-Rho-associated kinase (ROCK) activation (Lee et al., 2007).
Gene_expression (expresses) of LPA4 in neurite associated with neuroblastoma and shock
1) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.25 Pain Relevance 0
In addition to LPA2, LPA4 is highly expressed in normal ovarian tissues (Noguchi et al., 2003).
Gene_expression (expressed) of LPA4
2) Confidence 0.35 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 1.22 Pain Relevance 0.08
This response is likely to be mediated through LPA4, which, in contrast to the EDG family receptors, elevates cAMP and is highly expressed in the ovary (Noguchi et al., 2003).
Gene_expression (expressed) of LPA4 in ovary
3) Confidence 0.30 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.57 Pain Relevance 0
Among the six LPA receptors, LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6, LPA1 receptor is the main subtype expressed in the DRG neurons [11].
Gene_expression (expressed) of LPA4 in neurons associated with dorsal root ganglion
4) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.79 Pain Relevance 0.88
Alternatively, P2X2 receptors may normally mediate ATP-induced contractions of the longitudinal muscle but that there are compensatory changes in purinergic receptor expression in P2X2 KO mice.
Gene_expression (expression) of purinergic receptor in longitudinal muscle associated with targeted disruption
5) Confidence 0.05 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.22 Pain Relevance 0
For a recent review of purinergic receptor expression patterns and functions please see [29].
Gene_expression (expression) of purinergic receptor
6) Confidence 0.01 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0.46 Pain Relevance 0.41
Essentially all leukocyte populations express members of the P2 purinergic receptor superfamily; several recent reviews have detailed receptor expression patterns and the reader is directed to these for a more complete description [12, 13].
Gene_expression (express) of purinergic receptor in leukocyte
7) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.41 Pain Relevance 0.30

General Comments

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