INT217050

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Anatomy Link Frequency
macrophages 4
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 58 100.00 Very High Very High Very High
cytokine 10 97.48 Very High Very High Very High
Inflammatory response 8 97.48 Very High Very High Very High
Inflammation 58 97.08 Very High Very High Very High
Inflammatory stimuli 5 86.60 High High
Analgesic 1 77.88 Quite High
IPN 1 77.12 Quite High
Inflammatory mediators 2 75.04 Quite High
agonist 22 61.36 Quite High
Arthritis 1 56.32 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 97.48 Very High Very High Very High
Inflammatory Pain 1 77.12 Quite High
Infection 35 74.32 Quite High
Disease 10 57.44 Quite High
Arthritis 1 56.32 Quite High
Necrosis 11 51.56 Quite High
Neuropathic Pain 2 51.44 Quite High
Cancer 4 51.20 Quite High
Targeted Disruption 6 41.12 Quite Low
Sprains And Strains 7 39.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The membranes were then incubated in 1:3,000 HRP-donkey anti-goat Ig for A2BAR detection (Santa Cruz).
Positive_regulation (incubated) of Gene_expression (detection) of A2BAR
1) Confidence 0.50 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0 Pain Relevance 0
Inducible Adora2b expression may therefore contribute to feedback regulation of macrophage inflammatory responses.


Positive_regulation (Inducible) of Gene_expression (expression) of Adora2b in macrophage associated with inflammatory response
2) Confidence 0.37 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.49 Pain Relevance 0.52
upregulates expression of the adenosine receptor, A2B, and the activation of A2B receptors is involved with the deactivation of macrophages, possibly through an increase of cAMP [70].
Positive_regulation (upregulates) of Gene_expression (expression) of A2B in macrophages associated with adenocard
3) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096763 Disease Relevance 0.71 Pain Relevance 0.39

General Comments

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