INT217095

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr2) intracellular (Egr2) DNA binding (Egr2)
ligase activity (Egr2) cytoplasm (Egr2)
Anatomy Link Frequency
cortex 2
hippocampus 2
Egr2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 4 98.92 Very High Very High Very High
Hippocampus 20 98.52 Very High Very High Very High
long-term potentiation 16 91.84 High High
withdrawal 4 89.36 High High
opiate 4 88.92 High High
dopamine receptor 4 88.04 High High
narcan 7 57.24 Quite High
Pyramidal cell 2 23.48 Low Low
Central nervous system 4 10.36 Low Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 40 95.00 High High
Brain Hemorrhage 4 84.84 Quite High
Convulsion 8 81.56 Quite High
Lifespan 2 55.36 Quite High
Syndrome 2 49.04 Quite Low
Disease 2 47.88 Quite Low
Charcot Marie Tooth Disease 4 47.04 Quite Low
Neuropathic Pain 2 46.44 Quite Low
Cognitive Disorder 40 45.52 Quite Low
Peripheral Neuropathy 6 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge, the only available study in which the expression of Egr2 was examined after behavioural learning showed no evidence for a regulated expression of Egr2 in structures such as the amygdala, hippocampus or cortex that could be attributed to learning in a single-trial contextual fear conditioning paradigm (Malkani and Rosen, 2000).
Regulation (regulated) of Gene_expression (expression) of Egr2 in cortex associated with anxiety disorder, hippocampus and amygdala
1) Confidence 0.62 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.32 Pain Relevance 0.32
Alternatively, the present study also considers that abnormal inspiratory control in vivo may result from behavioral adaptation to r3-r5 defects in which Krox20 expression is altered but not entirely eliminated.
Neg (not) Regulation (altered) of Gene_expression (expression) of Krox20
2) Confidence 0.60 Published 2007 Journal Neural Develop Section Body Doc Link PMC2098766 Disease Relevance 0 Pain Relevance 0.03
Western blotting analyses were conducted to assess constitutive and regulated levels of Egr1, Egr2 and Egr3 in the dentate gyrus and CA1 of the hippocampus from WT, HT and cKO mice (n?
Regulation (regulated) of Gene_expression (levels) of Egr2 in hippocampus associated with hippocampus
3) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05

General Comments

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