INT217369

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoa4) transport (Apoa4) extracellular space (Apoa4)
extracellular region (Apoa4) cytoplasm (Apoa4)
Apoa4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 30.72 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
Hippocampus 18 5.00 Very Low Very Low Very Low
long-term potentiation 8 5.00 Very Low Very Low Very Low
Thalamus 8 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Limbic system 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 38 97.16 Very High Very High Very High
Targeted Disruption 171 88.84 High High
Alzheimer's Dementia 160 84.76 Quite High
Disorder Of Lipid Metabolism 4 23.28 Low Low
Cognitive Disorder 27 5.00 Very Low Very Low Very Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Vascular Disease 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Frailty 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overexpression of ApoE4 in a hAPP mouse, knocked out for ApoE, increases the number of focal, amyloid deposits tenfold in comparison with the ApoE3 mice [133].
Positive_regulation (overexpression) of Gene_expression (overexpression) of ApoE4 associated with amyloid plaque
1) Confidence 0.01 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.71 Pain Relevance 0

General Comments

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