INT217732

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 3.19
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
muscle 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 13 61.24 Quite High
gABA 3 25.92 Quite Low
headache 1 22.96 Low Low
Neurotransmitter 2 19.20 Low Low
Glutamate 4 17.04 Low Low
Spinal cord 3 14.76 Low Low
Inflammation 11 10.32 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 169 99.48 Very High Very High Very High
Muscular Atrophy 54 98.82 Very High Very High Very High
Frailty 15 95.88 Very High Very High Very High
Cancer 30 95.44 Very High Very High Very High
Hypertrophy 1 95.40 Very High Very High Very High
Breast Cancer 31 94.72 High High
Obstructive Sleep Apnea 73 92.48 High High
Obesity 18 91.04 High High
Hypoxia 43 90.12 High High
Hyperglycemia 2 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the context of muscle atrophy, lower Akt activity decreases the activation of mammalian target of rapamycin (mTOR), leading to decreased protein synthesis and ribosomal biogenesis, as well as decreased mitochondrial biogenesis and function, as mTOR has been shown to regulate mitochondrial gene expression through the regulation of YY1/PGC-1?
Localization (target) of mTOR in muscle associated with muscular atrophy
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.35 Pain Relevance 0
In vitro data suggest that mTOR inhibition can lead to a paradoxical increase in Akt activation, via a release of negative feedback on upstream signaling through insulin-like growth factor-1 receptor (IGF1R) [53], or direct activation by the rapamycin-insensitive mTOR-rictor complex [54].
Localization (release) of mTOR
2) Confidence 0.49 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.62 Pain Relevance 0
Exemplified by the total mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, they found a slight decrease in its protein content, unfortunately with no measures of its phosphorylation status or activity [11].
Localization (target) of mTOR
3) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004931 Disease Relevance 0.37 Pain Relevance 0
Most recently it was shown that central activation of mammalian target of rapamycin (mTOR), a serine/threonine kinase that operates as sensor of cellular energy status, stimulated LH secretion in pubertal female rats via modulation of hypothalamic KiSS-1, whereas mTOR blockade by rapamycin inhibited gonadotropic axis suggesting that central mTOR signaling has a role in the control of puberty onset and gonadotropin secretion [19].
Localization (target) of mTOR
4) Confidence 0.45 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2958977 Disease Relevance 0.22 Pain Relevance 0
For phosphorylated forms of PKB (PKB Ser473), mTOR (mTOR Ser2448), p70S6k (p70S6k Thr389), eIF-4E-BP1 (eIF-4E-BP1 Thr37/46), eukaryotic elongation factor 2 (eEF2 Thr56), and glycogen synthase kinase 3-?
Localization (forms) of mTOR
5) Confidence 0.35 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
For phosphorylated forms of PKB (PKB Ser473), mTOR (mTOR Ser2448), p70S6k (p70S6k Thr389), eIF-4E-BP1 (eIF-4E-BP1 Thr37/46), eukaryotic elongation factor 2 (eEF2 Thr56), and glycogen synthase kinase 3-?
Localization (forms) of mTOR
6) Confidence 0.35 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
There is evidence that the action of signaling molecules such as PKB, mammalian target of rapamycin (mTOR), p70 S6 kinase (p70S6k), and 4E-binding protein-1 (4E-BP1), as in rats (17, 19), is involved in the modulation of human MPS since these are also activated after increased amino acid provision (8, 12, 12, 20, 21).
Localization (target) of mTOR
7) Confidence 0.35 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
When BCAA are administered during and after resistance exercise, phosphorylation of the mammalian target of rapamycin (mTOR) leads to a sequence of (anabolic) enzymatic activations that are not seen to equal extent when BCAA are withheld [23].
Localization (target) of mTOR
8) Confidence 0.31 Published 2006 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129153 Disease Relevance 0 Pain Relevance 0
Even H2O2 at a concentration of 82.5 mM did not significantly decrease FRAP (587 ± 12 ?
Neg (not) Localization (decrease) of FRAP
9) Confidence 0.27 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0.90 Pain Relevance 0
Decreased FRAP could result from decreased membrane extraction or from impaired recruitment of unbleached Rab7 onto target membranes.
Localization (Decreased) of FRAP
10) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.30 Pain Relevance 0.03
Notably, the decreased rate of FRAP and FLAP in disease mutants was much less pronounced than in the Q67L mutant (Fig. 5D–G).
Localization (rate) of FRAP associated with disease
11) Confidence 0.12 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.42 Pain Relevance 0

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