INT217802

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
Anatomy Link Frequency
colon 2
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 1 57.40 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 48 100.00 Very High Very High Very High
Colon Cancer 21 100.00 Very High Very High Very High
Apoptosis 23 95.92 Very High Very High Very High
Disease 9 66.00 Quite High
Myeloproliferative Disorder 45 51.60 Quite High
Chronic Myeloid Leukemia 4 48.88 Quite Low
Myeloid Leukemia 25 44.48 Quite Low
Myelofibrosis 30 32.36 Quite Low
Philadelphia Chromosome 1 30.00 Quite Low
Myelodysplastic Syndromes 38 24.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.
Regulation (deregulated) of Transcription (deletion) of p53 in colon associated with cancer and colon cancer
1) Confidence 0.37 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0
Amongst the non-histone acetylation targets that via HDACi induced acetylation could potentially impart anti-cancer effect are transcription factors (p53, c-Myc, Smad7, BCL6, GATA, STAT3, NF-?
Regulation (targets) of Transcription (transcription) of p53 associated with cancer
2) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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