INT217802

Context Info Confidence 0.37 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.81 Pain Relevance 0.03

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53) endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)

Anatomy Link Frequency colon 2 TP53 (Homo sapiens)

Pain Link Frequency Relevance Heat Nicotine 1 57.40 cytokine 3 5.00 palliative 2 5.00 chemokine 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Cancer 48 100.00 Colon Cancer 21 100.00 Apoptosis 23 95.92 Disease 9 66.00 Myeloproliferative Disorder 45 51.60 Chronic Myeloid Leukemia 4 48.88 Myeloid Leukemia 25 44.48 Myelofibrosis 30 32.36 Philadelphia Chromosome 1 30.00 Myelodysplastic Syndromes 38 24.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Previous studies from our laboratory have identified a number of miRNAs that were deregulated in colon cancer cell lines due to the deletion of the p53 tumor suppressor gene.

Regulation (deregulated) of Transcription (deletion) of p53 in colon associated with cancer and colon cancer

1) Confidence 0.37 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0

Amongst the non-histone acetylation targets that via HDACi induced acetylation could potentially impart anti-cancer effect are transcription factors (p53, c-Myc, Smad7, BCL6, GATA, STAT3, NF-?

Regulation (targets) of Transcription (transcription) of p53 associated with cancer

2) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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