INT218009

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AHR, CYP27B1) mitochondrion (CYP27B1) immune system process (AHR)
small molecule metabolic process (CYP27B1) cell morphogenesis (AHR) DNA binding (AHR)
AHR (Homo sapiens)
CYP27B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 97.46 Very High Very High Very High
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 57.16 Quite High
Body Weight 3 5.00 Very Low Very Low Very Low
Lymphopenia 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Disease Susceptibility 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Feminization 1 5.00 Very Low Very Low Very Low
Nephrotoxicity 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An antagonistic effect of estrogen on effluent-stimulated CYP1A activities [presumably due to the presence of aryl hydrocarbon receptor (AhR) agonists such as PAHs, PCBs, and dioxins] is in agreement with previous evidence for inhibitory effects of estrogens on both basal and AhR-induced CYP1A activities in fish tissues (e.g., Mdegela et al. 2006; Navas and Segner 2000).
AhR Positive_regulation (induced) of CYP1A associated with agonist
1) Confidence 0.16 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.06 Pain Relevance 0.05

General Comments

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