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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INSR) endosome (INSR) plasma membrane (INSR)
nucleus (INSR) carbohydrate metabolic process (INSR)
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
tramadol 120 100.00 Very High Very High Very High
Central nervous system 3 74.88 Quite High
Opioid 16 68.36 Quite High
depression 2 67.00 Quite High
monoamine 2 60.68 Quite High
tricyclic antidepressant 1 54.44 Quite High
Serotonin 4 52.56 Quite High
Analgesic 28 39.64 Quite Low
alcohol 2 37.60 Quite Low
COX-2 inhibitor 13 19.60 Low Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 3 97.60 Very High Very High Very High
Respiratory Failure 1 67.00 Quite High
Convulsion 5 59.52 Quite High
Constipation 4 58.40 Quite High
Vomiting 4 57.28 Quite High
Dizziness 4 56.32 Quite High
Targeted Disruption 5 49.68 Quite Low
Poisoning 1 37.08 Quite Low
Ulcers 2 22.84 Low Low
Cardiovascular Disease 1 22.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These model structures include the possibility for multiple binding of insulin to the IR (?
Protein_catabolism (multiple) of IR
1) Confidence 0.29 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
Tramadol ER vs tramadol IR
Protein_catabolism (Tramadol) of IR associated with tramadol
2) Confidence 0.13 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386353 Disease Relevance 0.67 Pain Relevance 1.73
GRB10 also interferes with insulin signaling [31], [32], in part by mediating degradation of the insulin receptor [33], but the 3-fold increase in insulin receptor gene expression in women (Table 2) could serve to minimize any negative effect on insulin sensitivity that increased GRB10 expression might have.
Protein_catabolism (degradation) of insulin receptor
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0

General Comments

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