INT218696

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.36
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
kidney 4
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 33 98.44 Very High Very High Very High
Inflammation 27 95.48 Very High Very High Very High
Hippocampus 17 92.24 High High
fibrosis 23 91.92 High High
cytokine 10 85.64 High High
chemokine 3 80.80 Quite High
metalloproteinase 10 69.80 Quite High
antidepressant 22 41.28 Quite Low
Serotonin 1 17.80 Low Low
anesthesia 6 13.84 Low Low
Disease Link Frequency Relevance Heat
Stress 40 100.00 Very High Very High Very High
Ureteral Obstruction 75 98.16 Very High Very High Very High
INFLAMMATION 24 95.48 Very High Very High Very High
Urological Neuroanatomy 3 94.08 High High
Apoptosis 19 93.68 High High
Injury 19 93.48 High High
Internal Fibrosis 3 92.20 High High
Fibrosis 63 87.16 High High
Cancer 2 78.64 Quite High
Disease 3 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rather, they were associated with the inhibition of oxidative stress and smad2 phosphorylation.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of smad2 associated with stress
1) Confidence 0.42 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.50 Pain Relevance 0.38
In addition, we have shown that juglone inhibits the phosphorylation of smad2 an important redox-sensitive, profibrotic signaling molecule in the kidney [7,16,17].
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of smad2 in kidney
2) Confidence 0.42 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.13 Pain Relevance 0.09
Although it is unclear whether the inhibition of smad2 phosphorylation was a direct effect or a downstream event secondary to juglone's antioxidant characteristics in our model, smad2 inhibition has been successful in experimental studies of native and transplants kidney fibrosis [7,16,17].


Spec (whether) Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of smad2 in kidney associated with fibrosis and internal fibrosis
3) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.03 Pain Relevance 0.08
signalling pathways, NIM811 enhanced the phosphorylation of JNK and p38, but not extracellular signal-regulated kinases 1 and 2, and suppressed the phosphorylation of Smad2 and Smad3, accompanied by increased Smad7 transcription and decreased TGF-?
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of Smad2
4) Confidence 0.17 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.54 Pain Relevance 0.09
In contrast to TIEG1, Smad2 phosphorylation is
Negative_regulation (is) of Phosphorylation (phosphorylation) of Smad2
5) Confidence 0.10 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.16 Pain Relevance 0.29

General Comments

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