INT21877

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Context Info
Confidence 0.52
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 6.85
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Serpind1) biological_process (Serpind1)
Anatomy Link Frequency
muscle 1
veins 1
Serpind1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
peripheral neuropathy 9 95.36 Very High Very High Very High
Angina 1 94.08 High High
alcohol 13 86.60 High High
agonist 23 84.00 Quite High
Dopamine 47 83.68 Quite High
antidepressant 9 83.12 Quite High
Central nervous system 6 81.72 Quite High
tricyclic antidepressant 3 79.24 Quite High
cva 1 77.52 Quite High
Serotonin 3 76.20 Quite High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 559 100.00 Very High Very High Very High
Thrombosis 3 99.66 Very High Very High Very High
Cramps 4 99.16 Very High Very High Very High
Peripheral Neuropathy 9 95.36 Very High Very High Very High
Angina 1 94.08 High High
Fever 1 93.60 High High
Pressure And Volume Under Development 1 93.20 High High
Increased Venous Pressure Under Development 6 89.84 High High
Myxoma 1 86.72 High High
Diabetes Mellitus 12 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Right ventricular thrombosis due to familial heparin cofactor II deficiency].
Negative_regulation (deficiency) of heparin cofactor II associated with thrombosis
1) Confidence 0.52 Published 1990 Journal Kyobu Geka Section Title Doc Link 2214444 Disease Relevance 0.71 Pain Relevance 0.16
Procedures to reduce incompetent veins have not been shown to reduce RLS symptoms (Kanter 1995; Bradbury et al 1999).
Negative_regulation (reduce) of RLS in veins associated with restless legs syndrome
2) Confidence 0.49 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936366 Disease Relevance 2.20 Pain Relevance 0.50
A Japanese study found that 1.1% reported RLS symptoms; however, contrary to the pattern in Europe, symptoms were more common in men.
Negative_regulation (reported) of RLS associated with restless legs syndrome
3) Confidence 0.36 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936366 Disease Relevance 1.21 Pain Relevance 0.07
Others, perhaps misdiagnosing RLS as related to muscle cramps, use quinine, which has been shown to be ineffective in RLS (Van Dijk et al 1991).


Negative_regulation (ineffective) of RLS in muscle associated with cramps and restless legs syndrome
4) Confidence 0.36 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936366 Disease Relevance 1.78 Pain Relevance 0.19
Given that the criterion was surpassed in TREAT RLS 2, and very narrowly missed in TREAT RLS 1, it was considered acceptable for the overall life impact score to be calculated.
Negative_regulation (missed) of RLS 1 associated with restless legs syndrome
5) Confidence 0.28 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1322229 Disease Relevance 0.94 Pain Relevance 0

General Comments

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