INT218807

From wiki-pain
Revision as of 11:22, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.08
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Anatomy Link Frequency
neurons 2
brain 1
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 67 100.00 Very High Very High Very High
long-term potentiation 103 99.48 Very High Very High Very High
Eae 50 99.20 Very High Very High Very High
Hippocampus 65 96.60 Very High Very High Very High
amygdala 5 95.60 Very High Very High Very High
hyperexcitability 2 87.28 High High
Pyramidal cell 18 86.88 High High
Acute pain 1 85.84 High High
5HT 11 68.48 Quite High
cocaine 1 62.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 114 99.30 Very High Very High Very High
Convulsion 13 98.28 Very High Very High Very High
Thiamine Deficiency 62 95.92 Very High Very High Very High
Anxiety Disorder 61 94.36 High High
Shock 36 92.40 High High
Hypesthesia 1 91.80 High High
Epilepsy 9 87.88 High High
Pain 6 85.84 High High
Neurological Disease 3 83.96 Quite High
Cancer 9 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to quantify the loss of GluR2 mRNA, we analyzed the percentage of neurons that contain GluR2 mRNA at 6 and 8 weeks of age in control and GluR2-cKO mice in these brain regions (Fig. 1H).
Transcription (at) of GluR2 in brain
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.27
Consistently, we found increased AMPA receptor-mediated synaptic transmission and reduced LTP in hippocampal CA1 neurons.
Transcription (transmission) of AMPA in neurons associated with long-term potentiation
2) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.18 Pain Relevance 0.48
Direct sequencing of the RT-PCR products demonstrated that there was a Q/R site editing of GluR2 mRNA in cultured cortical neurons (Figure 3A).
Transcription (editing) of GluR2 in neurons
3) Confidence 0.33 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3006372 Disease Relevance 0.70 Pain Relevance 0.08
Although the molecular mechanism for epileptogenesis in these transgenic mice has not been elucidated, pre-editing of the GluR-B mRNA through genomic mutation rescues the seizure phenotype, suggesting that it is the changes in the AMPA channel properties are the cause.
Transcription (editing) of GluR-B associated with targeted disruption and convulsion
4) Confidence 0.09 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 1.20 Pain Relevance 0.08
The effect of the AMPA receptor antagonist and MGS0039 on the locomotor activity of mice
Transcription (antagonist) of AMPA associated with eae and antagonist
5) Confidence 0.06 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.54
An important set of proteins that was recovered using the TAP method consisted of the AMPA (?
Transcription (consisted) of AMPA
6) Confidence 0.03 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox