INT218812

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.85
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Ppp1r9a)
Anatomy Link Frequency
pyramidal neurons 2
hippocampus 1
Ppp1r9a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 105 100.00 Very High Very High Very High
Hippocampus 84 100.00 Very High Very High Very High
long-term potentiation 385 99.56 Very High Very High Very High
depression 273 98.88 Very High Very High Very High
Pyramidal cell 42 98.64 Very High Very High Very High
Glutamate 7 97.84 Very High Very High Very High
addiction 14 78.64 Quite High
Pain 7 49.68 Quite Low
tail-flick 28 44.00 Quite Low
amygdala 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 630 100.00 Very High Very High Very High
Congenital Anomalies 7 99.24 Very High Very High Very High
Depression 273 98.88 Very High Very High Very High
Shock 49 97.20 Very High Very High Very High
Anxiety Disorder 196 90.40 High High
Pain 14 49.68 Quite Low
Nociception 21 37.60 Quite Low
Hypesthesia 7 5.00 Very Low Very Low Very Low
Injury 7 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, it was found that acute expression of neurabin deletion mutant decreases mEPSC amplitude in cultured hippocampal slice [25], [34].
Gene_expression (expression) of neurabin
1) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.38 Pain Relevance 0.03
Therefore, the deletion of neurabin abolished LTP in hippocampal CA1 pyramidal neurons.
Gene_expression (deletion) of neurabin in pyramidal neurons associated with pyramidal cell and long-term potentiation
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.10 Pain Relevance 0.75
6), suggesting that the deletion of neurabin did not cause any developmental defect that would interfere with the shock-induced freezing response.
Gene_expression (deletion) of neurabin associated with congenital anomalies and shock
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.78 Pain Relevance 0.29
Taken together, these results suggest that neurabin contributes selectively to LTP but not LTD in the hippocampal CA1 pyramidal neurons.
Gene_expression (contributes) of neurabin in pyramidal neurons associated with depression, pyramidal cell and long-term potentiation
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.97 Pain Relevance 0.58
Using virus-mediated expression of mutant neurabin, which is unable to bind PP1 or F-actin, it was found to attenuate LTD, increase LTP and decrease basal synaptic transmission in hippocampal slice culture [25], [26].
Gene_expression (expression) of neurabin associated with depression and long-term potentiation
5) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.63 Pain Relevance 0.44
However, the results may reflect a preferential synaptic expression of AMPARs in the neurabin KO mice.
Gene_expression (expression) of neurabin KO associated with targeted disruption
6) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.15 Pain Relevance 0.25
We further examined the expression of different subunits of NMDA receptors, NR1, NR2A and NR2B in hippocampus of wild-type and neurabin KO mice.
Spec (examined) Gene_expression (expression) of neurabin KO in hippocampus associated with targeted disruption, nmda receptor and hippocampus
7) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.84 Pain Relevance 0.42

General Comments

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