INT218916

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.31
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Alpi)
Anatomy Link Frequency
osteoblasts 1
cortex 1
hippocampus 1
Alpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 172 97.76 Very High Very High Very High
Hippocampus 6 95.76 Very High Very High Very High
Nerve growth factor 6 86.40 High High
withdrawal 38 64.32 Quite High
cINOD 10 12.68 Low Low
Inflammation 16 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 516 100.00 Very High Very High Very High
Disease 86 96.16 Very High Very High Very High
Osteoporosis 108 82.32 Quite High
Death 60 68.96 Quite High
Toxicity 4 45.88 Quite Low
Drug Induced Neurotoxicity 4 38.24 Quite Low
Repression 4 32.40 Quite Low
INFLAMMATION 26 12.16 Low Low
Aging 20 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to explore the possible downstream effectors of GC-induced apoptosis further, we employed rtqPCR to examine the expression of the major families of prosurvival genes (Bcl-2, Bcl-XL, IAP-1, IAP-2, XIAP, FLIPLong and FLIPShort) in osteoblasts subjected to high-dose Dex.
Spec (examine) Gene_expression (expression) of IAP-1 in osteoblasts associated with apoptosis and dexamethasone
1) Confidence 0.10 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.55 Pain Relevance 0.23
Briefly, gene transcript levels of the GC-insensitive house keeping gene, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the anti-apoptotic mouse genes Bcl-2, Bcl-XL, IAP-1, IAP-2, X-linked IAP (XIAP), FLIPLong and FLIPShort were quantified by rtqPCR on a LightCycler (Roche Diagnostic Systems).
Gene_expression (quantified) of IAP-1 associated with apoptosis
2) Confidence 0.09 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.29 Pain Relevance 0.03
 ; mouse IAP-1 (accession no.
Gene_expression (accession) of IAP-1
3) Confidence 0.09 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.12 Pain Relevance 0
The transcript levels of anti-apoptotic proteins Bcl-2, IAP-1, FLIPLong and FLIPShort were not detectably altered by Dex treatment.
Gene_expression (levels) of IAP-1 associated with apoptosis and dexamethasone
4) Confidence 0.08 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.51 Pain Relevance 0.45
Using mRNA microarrays, Watanabe et al. found that EGb761 was able to up-regulate gene expression of microtubuli-associated tau protein as well as of neural protein phosphatase type 1, a serine/threonine protein phosphatase known to dephosphorylate hyperphosphorylated tau protein, in the hippocampus and cortex of normal mice [5,87].
Gene_expression (expression) of phosphatase type 1 in hippocampus associated with hippocampus
5) Confidence 0.01 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.42 Pain Relevance 0.17
Using mRNA microarrays, Watanabe et al. found that EGb761 was able to up-regulate gene expression of microtubuli-associated tau protein as well as of neural protein phosphatase type 1, a serine/threonine protein phosphatase known to dephosphorylate hyperphosphorylated tau protein, in the hippocampus and cortex of normal mice [5,87].
Gene_expression (expression) of phosphatase type 1 in cortex associated with hippocampus
6) Confidence 0.00 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.42 Pain Relevance 0.17

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