INT218929

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pts, Ephb1) endosome (Ephb1) signal transduction (Ephb1)
mitochondrion (Pts) lyase activity (Pts) plasma membrane (Ephb1)
Pts (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 43 67.36 Quite High
cINOD 2 38.00 Quite Low
withdrawal 7 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 110 91.20 High High
Repression 1 57.72 Quite High
INFLAMMATION 1 37.48 Quite Low
Breast Cancer 1 22.56 Low Low
Death 13 14.80 Low Low
Osteoporosis 27 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vanadate-sensitive PTPs like PTP-1B inactivate ERK and Akt/PK B indirectly by dephosphorylating upstream growth factor receptors and insulin receptor substrates, thereby preventing tyrosine-dependent docking of molecules like shc, grb2 or PI3-kinase (Neel & Tonks 1997, Elchebly et al. 1999, Galic et al. 2005).
PTPs Negative_regulation (inactivate) of ERK
1) Confidence 0.05 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.69 Pain Relevance 0.03

General Comments

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