INT219057

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.58
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Polr2f) nucleus (Polr2f) DNA binding (Polr2f)
Polr2f (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 55 88.72 High High
imagery 84 82.08 Quite High
Inflammation 1 73.60 Quite High
Sciatic nerve 16 42.24 Quite Low
Peripheral nervous system 2 34.88 Quite Low
IPN 2 31.28 Quite Low
isoflurane 22 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 136 99.80 Very High Very High Very High
Cytomegalovirus Infection 190 96.88 Very High Very High Very High
Ganglion Cysts 55 88.72 High High
Repression 63 80.40 Quite High
Targeted Disruption 40 78.72 Quite High
Cancer 323 78.00 Quite High
Toxicity 2 74.56 Quite High
INFLAMMATION 1 73.60 Quite High
Inflammatory Pain 2 31.28 Quite Low
Severe Combined Immunodeficiency 14 26.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although, as described above, HSV has been previously shown to express shRNA, this is the first demonstration of HSV-mediated expression of shRNA from a pol II miRNA-based system.
Gene_expression (expression) of pol II associated with cold sores
1) Confidence 0.13 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.63 Pain Relevance 0.08
We conclude that the retroviral pHUSH vector is capable of inducible pol III-shRNA expression, pol II-miRNA expression, and pol II-protein expression.
Gene_expression (expression) of pol II
2) Confidence 0.11 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.14 Pain Relevance 0.04
These 'second-generation' miRNA mimetics can be expressed from Pol II promoters, allowing the use of established conditional expression vectors [20,21].
Gene_expression (expressed) of Pol II
3) Confidence 0.09 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.07 Pain Relevance 0
Importantly, we compare a number of different shRNA and miRNA configurations in transient transfection assays and show that the pHUSH backbone is effective at providing regulated expression from both pol II and pol III promoters, thereby enabling regulated shRNA, miRNA and protein expression.
Gene_expression (expression) of pol II
4) Confidence 0.08 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0 Pain Relevance 0
Unlike the N19 shRNA design, the miRNA mimetic can be expressed as standard pol II transcripts, which are then processed by the nuclear Drosha, and cytoplasmic Dicer endonucleases to form a 21–22 nt active siRNA [31].
Gene_expression (expressed) of pol II
5) Confidence 0.08 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.26 Pain Relevance 0
Importantly, we compare a number of different shRNA and miRNA configurations in transient transfection assays and show that the pHUSH backbone is effective at providing regulated expression from both pol II and pol III promoters, thereby enabling regulated shRNA, miRNA and protein expression.
Gene_expression (expression) of pol II
6) Confidence 0.08 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0 Pain Relevance 0
We conclude that the retroviral pHUSH vector is capable of inducible pol III-shRNA expression, pol II-miRNA expression, and pol II-protein expression.
Gene_expression (expression) of pol II-miRNA
7) Confidence 0.08 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.14 Pain Relevance 0.04
"First generation" pol III-shRNA vectors, "second generation" pol II-miRNA, and protein expression vectors have been successfully developed as components for inducible expression on several backbones.
Gene_expression (expression) of pol II-miRNA
8) Confidence 0.07 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2174931 Disease Relevance 0.34 Pain Relevance 0

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