INT219135

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.52
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 82 98.96 Very High Very High Very High
Inflammation 112 92.72 High High
antagonist 6 84.72 Quite High
chemokine 11 84.04 Quite High
cytokine 34 83.44 Quite High
anakinra 1 83.12 Quite High
Inflammatory response 12 80.08 Quite High
vagus nerve 2 75.84 Quite High
agonist 7 53.60 Quite High
Arthritis 7 31.28 Quite Low
Disease Link Frequency Relevance Heat
Disease 127 100.00 Very High Very High Very High
Crystal Associated Disease 81 98.76 Very High Very High Very High
Plasmodium Infection 17 98.24 Very High Very High Very High
INFLAMMATION 122 92.72 High High
Sprains And Strains 3 92.48 High High
Syndrome 2 89.92 High High
Fever 20 87.00 High High
Parasitemia 4 82.32 Quite High
Infection 19 78.24 Quite High
Targeted Disruption 9 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?
Positive_regulation (mutated) of Gene_expression (/) of cryopyrin
1) Confidence 0.49 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.02 Pain Relevance 0.26
Also, given that common variants in the NLRP3 region have previously been associated with CD [3] and that the gene products of NLRP3 and MEFV (i.e.
Positive_regulation (variants) of Gene_expression (region) of NLRP3 associated with crohn's disease
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745755 Disease Relevance 1.26 Pain Relevance 0.49
The group of Tschopp discovered that many inorganic particles, including MSU and calcium pyrophosphate dihydrate crystals, are capable of activating the NLRP3 inflammasome to process and secrete active IL-1?
Positive_regulation (activating) of Gene_expression (process) of NLRP3 associated with crystal associated disease
3) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.44 Pain Relevance 0.03
and the NLRP3 inflammasome during malarial disease we infected IL-1?
Positive_regulation (infected) of Gene_expression (inflammasome) of NLRP3 associated with disease
4) Confidence 0.38 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.80 Pain Relevance 0.15

General Comments

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