INT219180

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.51
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR7) signal transduction (TLR7) endoplasmic reticulum (TLR7)
plasma membrane (TLR7) intracellular (TLR7) lysosome (TLR7)
Anatomy Link Frequency
corneal epithelium 1
TLR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 57 100.00 Very High Very High Very High
antagonist 34 100.00 Very High Very High Very High
Inflammation 105 99.16 Very High Very High Very High
Inflammatory response 73 92.32 High High
Pain 5 91.84 High High
cytokine 96 89.44 High High
psoriasis 14 85.52 High High
chemokine 29 67.44 Quite High
rheumatoid arthritis 7 59.72 Quite High
tolerance 18 47.00 Quite Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 70 99.86 Very High Very High Very High
Atherosclerosis 78 99.84 Very High Very High Very High
Herpes Simplex Virus 10 99.82 Very High Very High Very High
INFLAMMATION 177 99.16 Very High Very High Very High
Vomiting 4 96.64 Very High Very High Very High
Disease 176 96.48 Very High Very High Very High
Critical Illness 74 96.40 Very High Very High Very High
Fatigue 4 95.80 Very High Very High Very High
Fever 8 94.68 High High
Pain 4 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the expression of TLR7, 8 and 10 was not detected in the current study, it is still possible that the expression of these genes and proteins can be induced in vivo.
Gene_expression (expression) of TLR7
1) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.44 Pain Relevance 0.18
For example, it was recently found that herpes simplex virus induced TLR7 expression in human corneal cells [19].
Gene_expression (expression) of TLR7 associated with herpes simplex virus
2) Confidence 0.68 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.50 Pain Relevance 0.20
Protein validation of TLR7 expression
Gene_expression (expression) of TLR7
3) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.59 Pain Relevance 0.13
A recent study showed that herpes simplex virus, HSVI, induced the expression of TLR7 in corneal epithelium [19].
Gene_expression (expression) of TLR7 in corneal epithelium associated with herpes simplex virus
4) Confidence 0.53 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.31 Pain Relevance 0.07
However, the expression of TLR7 in atherosclerosis has not been reported before.
Gene_expression (expression) of TLR7 associated with atherosclerosis
5) Confidence 0.52 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.80 Pain Relevance 0.07
release have suggested a role for endogenous ATP (22, 24), we investigated whether CL075 and other TLR7/8 agonists induced IL-1?
Gene_expression (/) of TLR7 associated with agonist
6) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.21
g/ml acting predominantly at TLR7) did not give any detectable release of IL-1?
Gene_expression (acting) of TLR7
7) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.15
The expression of TLR3, TLR4, TLR7, TLR8 and TLR9 was significantly higher in mild cases than controls (p?
Gene_expression (expression) of TLR7
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.81 Pain Relevance 0.03
0.0009) and rise in TLR3, TLR4, TLR7 levels (p?
Gene_expression (levels) of TLR7
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 0.93 Pain Relevance 0.04
Novel approaches have been explored for the treatment of SLE using antagonists of TLR7/8/9 (G Lipford, Coley Pharmaceutical, MA) or TLR7/9 (R Coffman, Dynavax, CA).
Gene_expression (antagonists) of TLR7 associated with antagonist and systemic lupus erythematosus
10) Confidence 0.33 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.36 Pain Relevance 0.43
Novel approaches have been explored for the treatment of SLE using antagonists of TLR7/8/9 (G Lipford, Coley Pharmaceutical, MA) or TLR7/9 (R Coffman, Dynavax, CA).
Gene_expression (antagonists) of TLR7 associated with antagonist and systemic lupus erythematosus
11) Confidence 0.33 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.34 Pain Relevance 0.42
Intralesional interleukin-2 has also been given in combination with imiquimod, an agonist of toll-like receptor 7, with complete regression of 40.7% of 182 lesions treated, including cutaneous and subcutaneous lesions, and partial regression of 9.8%.63
Gene_expression (agonist) of toll-like receptor 7 associated with agonist
12) Confidence 0.08 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004577 Disease Relevance 1.71 Pain Relevance 0.19
Antimalarial drugs target TLR-7 and -9, and the development of a small oral molecule with similar actions has generated great interest from several companies (for example, ESAI (Woodcliff Lake, NJ, USA), Coley (Dusseldorff, Germany)/Xiphon (New Castle, Delaware, USA)/Pfizer (New York, NY, USA)).
Gene_expression (target) of TLR-7
13) Confidence 0.07 Published 2010 Journal BMC Med Section Body Doc Link PMC3009611 Disease Relevance 0.70 Pain Relevance 0.08

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