INT219288

Context Info Confidence 0.55 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0 Pain Relevance 0.55

transport (Kcnc1) transmembrane transport (Kcnc1)

Anatomy Link Frequency cerebellar granule cells 1 myometrium 1 brain 1 Kcnc1 (Mus musculus)

Pain Link Frequency Relevance Heat Pyramidal cell 16 94.72 potassium channel 4 86.52 Hippocampus 10 84.52 Calcium channel 1 77.96 Action potential 3 76.56 Thalamus 2 74.40 agonist 5 41.28 tetrodotoxin 2 5.00 Pain 2 5.00 repetitive firing 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 8 5.00 Disease 6 5.00 Sprains And Strains 3 5.00 Pain 2 5.00 Epilepsy 2 5.00 Adhesions 2 5.00 Motor Neuron Diseases 2 5.00 Autism 2 5.00 Infection 2 5.00 Dysmenorrhea 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is also some evidence for potassium currents in myometrium which are voltage gated [15], including evidence for the presence of Kv channels which are assumed to consist of multimers of ?

Localization (presence) of Kv in myometrium

1) Confidence 0.55 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2186335 Disease Relevance 0 Pain Relevance 0.20

Next, we analyzed in more detail the three brain areas where Kv4 protein localization and function have been best characterized.

Localization (localization) of Kv4 in brain

2) Confidence 0.55 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.18

A predominant dendritic localization of Kv4.2 proteins has also been observed in other neuronal populations such as in cerebellar granule cells (Rhodes et al., 2004; Sheng et al., 1992; Strassle et al., 2005).

Localization (localization) of Kv4 in cerebellar granule cells

3) Confidence 0.48 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2576564 Disease Relevance 0 Pain Relevance 0.17

General Comments

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