INT21933

Context Info Confidence 0.28 First Reported 1986 Last Reported 2010 Negated 3 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 5.48 Pain Relevance 5.29

plasma membrane (Pag1) intracellular (Pag1)

Anatomy Link Frequency LRF 2 PAG 2 Pag1 (Mus musculus)

Pain Link Frequency Relevance Heat Central grey 34 100.00 Periaqueductal grey 19 100.00 GABAergic 4 100.00 Opioid 6 99.98 Spinal cord 1 99.56 Antinociceptive 5 99.48 narcan 6 99.40 agonist 4 98.20 Neurotransmitter 2 96.68 Morphine 1 96.36

Disease Link Frequency Relevance Heat Urological Neuroanatomy 53 100.00 Bradycardia 4 100.00 Spinal Cord Injury 1 99.56 Diabetes Mellitus 10 98.68 Hyperalgesia 4 91.52 Peripheral Arterial Disease 1 89.76 Pressure Volume 2 Under Development 3 88.52 Nociception 1 75.00 Pain 1 51.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Systemic methysergide (2-6 mg/kg i.v.) selectively reduced PAG-evoked inhibition in 6 units, while inhibitions from both PAG and LRF stimulation were reduced in one unit and unaffected in 8 units.

Neg (unaffected) Regulation (unaffected) of Negative_regulation (inhibitions) of PAG in LRF associated with central grey

1) Confidence 0.28 Published 1990 Journal Brain Res. Section Abstract Doc Link 2224516 Disease Relevance 0.78 Pain Relevance 0.98

PAG inhibition of baroreflex vagal bradycardia was not affected following spinal cord transection at C1, indicating that the inhibition was exclusively central in origin and not due to peripheral, prejunctional inhibition of vagal acetylcholine release by increased cardiac sympathetic nerve activities.

Neg (not) Regulation (affected) of Negative_regulation (inhibition) of PAG in PAG associated with periaqueductal grey, bradycardia and spinal cord

2) Confidence 0.22 Published 1993 Journal Pflugers Arch. Section Abstract Doc Link 8414916 Disease Relevance 1.58 Pain Relevance 0.61

In contrast, PAG/NRD stimulation-produced inhibition of the VIR was unaffected by intravenous naloxone.

Neg (unaffected) Regulation (unaffected) of Negative_regulation (inhibition) of PAG associated with narcan and central grey

3) Confidence 0.20 Published 1986 Journal Brain Res. Section Abstract Doc Link 3697757 Disease Relevance 0.85 Pain Relevance 0.66

Here we report that opioid inhibition of GABAergic synaptic currents in the PAG is controlled by a presynaptic voltage-dependent potassium conductance.

Regulation (controlled) of Negative_regulation (inhibition) of PAG associated with periaqueductal grey, gabaergic and opioid

4) Confidence 0.17 Published 1997 Journal Nature Section Abstract Doc Link 9403690 Disease Relevance 0.43 Pain Relevance 1.62

It is concluded that down-regulation of TRPV1 receptors in PAG is responsible for reduced antinociceptive effect of TRPV1 agonist.

Regulation (responsible) of Negative_regulation (regulation) of PAG associated with agonist, antinociceptive and central grey

5) Confidence 0.01 Published 2010 Journal Brain Res. Section Abstract Doc Link 20211611 Disease Relevance 1.84 Pain Relevance 1.42

General Comments

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