INT21937

Context Info Confidence 0.39 First Reported 1989 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 16 Total Number 27 Disease Relevance 22.34 Pain Relevance 13.76

lyase activity (Scly) cytoplasm (Scly)

Anatomy Link Frequency finger 10 SAPS 1 sinus 1 Atrium 1 SNS 1 Scly (Mus musculus)

Pain Link Frequency Relevance Heat Multiple sclerosis 1476 100.00 lidocaine 30 99.82 Fibrositis 16 99.68 Pain 16 99.28 epidural 8 97.32 tetrodotoxin 3 94.40 Autonomic response 2 87.88 Biofeedback 4 85.40 Action potential 3 83.44 Face pain 1 81.00

Disease Link Frequency Relevance Heat Demyelinating Disease 1512 100.00 Fibromyalgia 7 99.68 Pain 13 99.28 Disorder Of Lipid Metabolism 108 99.16 Peripheral Arterial Disease 12 88.80 Sleep Disorders 4 85.80 Facial Neuralgia 1 81.36 Autoimmune Disease 12 78.56 Bruxism 1 75.00 Stress 3 67.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pain stimulation produced a significant increase in SCL and a significant decrease in BF at both the antebrachium and brachium.

Positive_regulation (increase) of SCL associated with pain

1) Confidence 0.39 Published 2002 Journal Nurs Health Sci Section Abstract Doc Link 12153407 Disease Relevance 0.68 Pain Relevance 0.87

In the presence of ryanodine, cesium significantly decreased D1 (-39.3%), shifted the late diastolic potential more negative, and increased SCL (+25.7%).

Positive_regulation (increased) of SCL

2) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.09

Ryanodine (10(-6) M) caused a small but significant initial decrease (-3.7%) followed by a progressive increase in SCL (+172%).

Positive_regulation (increase) of SCL

3) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.11

Verapamil (0.4-1.0 microM) progressively increased SCL by decreasing late diastolic slope, resulting in oscillatory potentials and eventual quiescence.

Positive_regulation (increased) of SCL

4) Confidence 0.37 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.14

Furthermore, an increase of the SCL during the period of treatment was observed for both groups in session I and II, while session III produced nearly stable values.

Positive_regulation (increase) of SCL

5) Confidence 0.36 Published 2001 Journal J Oral Rehabil Section Abstract Doc Link 11580823 Disease Relevance 0.16 Pain Relevance 0.23

Sinus cycle length (SCL) and Atrium-His (AH) interval increased by 9 and 11 per cent respectively (P less than 0.05), 30 min after TEL.

Positive_regulation (increased) of SCL in Atrium associated with lidocaine

6) Confidence 0.29 Published 1990 Journal Can J Anaesth Section Abstract Doc Link 2225302 Disease Relevance 0 Pain Relevance 1.22

Intravenous lidocaine did not increase either SCL or AH.

Neg (not) Positive_regulation (increase) of SCL associated with lidocaine

7) Confidence 0.29 Published 1990 Journal Can J Anaesth Section Abstract Doc Link 2225302 Disease Relevance 0 Pain Relevance 1.25

E-4031 (0.1-3 micromol/kg i.v.) increased the sinus cycle length (SCL) and SNRT dose dependently.

Positive_regulation (increased) of SCL in sinus

8) Confidence 0.28 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9456272 Disease Relevance 0 Pain Relevance 0

When SAP stimulation increased SCL, SNRT, CSNRT, and SACT, E-4031 selectively inhibited the prolongation of SCL by SAP stimulation but did not affect the prolongation of CSNRT or SACT.

Positive_regulation (increased) of SCL

9) Confidence 0.28 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9456272 Disease Relevance 0 Pain Relevance 0

We observed significant asymmetries of SEMG level, TEMP and SCL in the FMS Group.

Positive_regulation (asymmetries) of SCL associated with fibrositis

10) Confidence 0.24 Published 2006 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 17063406 Disease Relevance 0.74 Pain Relevance 0.51

Considering that the geographic incidence of MScl indicates an increase in MScl with a decrease in sunlight exposure, that vitamin D is produced in the skin by solar or UV irradiation and that high serum levels of 25-hydroxyvitamin D have been reported to correlate with a reduced risk of MScl, a protective role of vitamin D has been suggested [32].

Positive_regulation (increase) of MScl in skin associated with multiple sclerosis

11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.08 Pain Relevance 0.48

Another differentially abundant peptide was identified as a part apolipoprotein D, which has previously been shown to be elevated intrathecally in MScl patients [17].

Positive_regulation (elevated) of MScl associated with multiple sclerosis and disorder of lipid metabolism

12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 0.67 Pain Relevance 0.25

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis

13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.81 Pain Relevance 0.84

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis

14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.82 Pain Relevance 0.84

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis

15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.69 Pain Relevance 0.77

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis

16) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.67 Pain Relevance 0.76

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis

17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.87 Pain Relevance 0.87

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis

18) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.85 Pain Relevance 0.86

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of RR MScl in finger associated with multiple sclerosis

19) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.84 Pain Relevance 0.85

Additional proteins with low p-values in the comparisons of both MScl types with the controls include StAR-related lipid transfer protein 4 (2.551 fold increase in PP MScl compared to controls and 2.837 fold increase in RR MScl compared to controls), LON peptidase N-terminal domain and RING finger protein (2.847 fold increase in PP MScl and 2.212 fold increase in RR MScl), and ryanodine receptor 1 (2.129 fold increase in PP MScl and 1.877 fold increase in RR MScl).

Positive_regulation (increase) of PP MScl in finger associated with multiple sclerosis

20) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.82 Pain Relevance 0.84

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