INT21943

Context Info Confidence 0.46 First Reported 1987 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 6 Total Number 7 Disease Relevance 3.29 Pain Relevance 0.75

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT) extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)

Anatomy Link Frequency blood 2 renal artery 2 AGT (Homo sapiens)

Pain Link Frequency Relevance Heat Catecholamine 2 100.00 antagonist 4 91.92 epidural 2 87.80 anesthesia 2 75.00 Morphine 1 68.44 beta blocker 6 67.44 headache 6 66.96 ketamine 1 66.56 antiarrhythmic agent 3 64.88 Clonidine 5 60.24

Disease Link Frequency Relevance Heat Stress 8 99.98 Renal Artery Obstruction 5 99.98 Increased Venous Pressure Under Development 4 99.96 Pressure Volume 2 Under Development 6 96.96 Disorders Of Creatine Metabolism 1 91.00 Hypertension 81 89.76 Natriuresis 1 89.44 Heart Rate Under Development 17 88.32 Acute Renal Failure 3 87.12 Renal Disease 5 84.72

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Event

Anatomy

Negation

Speculation

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Disease term

The same stimulus also triggers an increase in the levels of circulating vasoactive hormones, such as norepinephrine and angiotensin II, further augmenting arteriolar tone.

Positive_regulation (augmenting) of Positive_regulation (increase) of angiotensin II

1) Confidence 0.46 Published 1993 Journal Physiologist Section Abstract Doc Link 11537414 Disease Relevance 0.57 Pain Relevance 0.06

In renal artery stenosis activation of the renin-angiotensin system elevates blood pressure by direct peripheral effects and probably through stimulation of sympathetic activity, which can be induced by angiotensin-II either centrally or peripherally.

Positive_regulation (elevates) of Positive_regulation (activation) of angiotensin in renal artery associated with renal artery obstruction

2) Confidence 0.45 Published 1987 Journal Clin Exp Hypertens A Section Abstract Doc Link 3315326 Disease Relevance 0.47 Pain Relevance 0.06

Furthermore, the negative effect of thiazides, of increasing free radical levels through induction of the renin–angiotensin system, could be counterbalanced by zofenopril's antioxidant effect in the combination.

Positive_regulation (increasing) of Positive_regulation (induction) of angiotensin

3) Confidence 0.41 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.40 Pain Relevance 0.07

In addition, HCTZ may increase oxidant activity via an activation of the renin–angiotensin system, and zofenopril has a direct antioxidant effect in humans (Napoli et al 2004).

Spec (may) Positive_regulation (increase) of Positive_regulation (activation) of angiotensin

4) Confidence 0.29 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.25 Pain Relevance 0

Operative stress leads to an increase in circulating catecholamines and angiotensin.

Positive_regulation (leads) of Positive_regulation (increase) of angiotensin associated with stress and catecholamine

5) Confidence 0.21 Published 1990 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 2278418 Disease Relevance 0.53 Pain Relevance 0.31

They block the activation of angiotensin II receptors via block of AT1 receptors, causing vasodilation, reduced of secretion of vasopressin, reduced production and secretion of aldosterone, and reduction of blood pressure.

Positive_regulation (causing) of Positive_regulation (activation) of angiotensin II in blood associated with increased venous pressure under development

6) Confidence 0.02 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2920560 Disease Relevance 0.83 Pain Relevance 0.18

It was initially thought that ACE inhibitors were likely to be most useful as antihypertensive agents in conditions in which circulating renin and angiotensin II were elevated.

Positive_regulation (elevated) of Positive_regulation (elevated) of angiotensin II

7) Confidence 0.02 Published 1990 Journal Drugs Section Abstract Doc Link 2226219 Disease Relevance 0.24 Pain Relevance 0.07

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