INT21957

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.34
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
blood 2
pulmonary artery 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 99.98 Very High Very High Very High
antagonist 44 92.64 High High
Calcitonin gene-related peptide 39 82.16 Quite High
qutenza 14 78.96 Quite High
agonist 22 77.04 Quite High
Neurotransmitter 4 51.60 Quite High
local anesthetic 1 50.00 Quite Low
anesthesia 3 25.00 Low Low
Potency 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 10 100.00 Very High Very High Very High
Hypoxia 8 100.00 Very High Very High Very High
Hypertrophy 1 99.34 Very High Very High Very High
Sudden Death 1 81.52 Quite High
Adult Respiratory Distress Syndrome 1 50.00 Quite Low
Disease 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 3 5.00 Very Low Very Low Very Low
Cardiovascular Disease 3 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, in anaesthetized rats, diltiazem inhibited ET-1-induced decreases in renal blood flow and increased renal accumulation of IR-ET-1.
Negative_regulation (inhibited) of Negative_regulation (decreases) of ET-1-induced in blood
1) Confidence 0.43 Published 1994 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 8027928 Disease Relevance 0.08 Pain Relevance 0
In animals given phosphoramidon (0.25 mg/kg per min i.v.), a metalloproteinase inhibitor, the hypertensive effect of big endothelin-1 was markedly attenuated.
Negative_regulation (attenuated) of Negative_regulation (inhibitor) of endothelin-1 associated with hypertension and metalloproteinase
2) Confidence 0.43 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226629 Disease Relevance 0.36 Pain Relevance 0.13
However, vasomotor tone rapidly recovered in absence of vasodilators and ET-1 (Fig. 2D).
Negative_regulation (recovered) of Negative_regulation (absence) of ET-1
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0 Pain Relevance 0.44
In mechanistic studies, ZD1611 decreased (P<0.01) smooth muscle hypertrophy of small pulmonary arteries and abolished hypoxia-induced decreases in sensitivity and maximum contraction to ET-1 in isolated extralobar branch pulmonary artery.
Negative_regulation (abolished) of Negative_regulation (decreases) of ET-1 in pulmonary artery associated with hypertrophy and hypoxia
4) Confidence 0.42 Published 1999 Journal Pulm Pharmacol Ther Section Abstract Doc Link 10545286 Disease Relevance 0.90 Pain Relevance 0.11
Lidocaine and mepivacaine are more effective in reducing PAP and edema formation, but long-acting local anesthetics also inhibit ET-1 depletion and therefore have increased anti-inflammatory properties.


Negative_regulation (inhibit) of Negative_regulation (depletion) of ET-1
5) Confidence 0.41 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19690261 Disease Relevance 0 Pain Relevance 0

General Comments

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