INT219595

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.81
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
macrophages 2
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 1 99.84 Very High Very High Very High
rheumatoid arthritis 17 99.16 Very High Very High Very High
Inflammation 52 93.76 High High
fibrosis 48 89.04 High High
Leflunomide 8 87.28 High High
methotrexate 9 84.80 Quite High
Arthritis 10 82.92 Quite High
Inflammatory response 6 75.08 Quite High
cytokine 45 56.76 Quite High
diclofenac 2 41.36 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 55 99.84 Very High Very High Very High
Rheumatoid Arthritis 17 99.16 Very High Very High Very High
Pulmonary Disease 4 98.12 Very High Very High Very High
Asthma 2 96.56 Very High Very High Very High
Disease 5 95.92 Very High Very High Very High
Pulmonary Fibrosis 28 89.04 High High
Necrosis 2 86.24 High High
Cancer 1 85.88 High High
Arthritis 9 82.92 Quite High
Experimental Arthritis 1 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess which of the PDE4 subtypes contribute to the activity recovered in the ?
Positive_regulation (recovered) of Gene_expression (recovered) of PDE4
1) Confidence 0.39 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
These results are consistent with the fact that PDE4 expression is induced by inflammatory stimulus and that it mediates activation and proliferation of T-cells and function of macrophages [25-28].
Positive_regulation (induced) of Gene_expression (expression) of PDE4 in macrophages associated with inflammatory stimuli
2) Confidence 0.32 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 1.50 Pain Relevance 0.59
In this study, we evaluated PDE4
Positive_regulation (evaluated) of Gene_expression (evaluated) of PDE4
3) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 1.31 Pain Relevance 0.52

General Comments

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