INT21983

Context Info Confidence 0.18 First Reported 1986 Last Reported 1999 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 2.90 Pain Relevance 0.67

peptidase activity (Cela1) extracellular region (Cela1)

Anatomy Link Frequency urine 1 Cela1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 5 96.48 abdominal pain 2 79.36 Pain score 1 77.12 Inflammation 1 62.32

Disease Link Frequency Relevance Heat Pancreatic Cancer 5 99.92 Pancreatitis 25 99.42 Disease 3 98.24 Abdominal Pain 2 79.36 Pain 1 77.12 Cholangitis 1 59.92 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Sensitivity of elastase 1 for the diagnosis "acute pancreatitis" was 97% after admission to the hospital and 100% within 48 h after onset of acute pancreatitis.

Regulation (Sensitivity) of elastase 1 associated with pancreatitis

1) Confidence 0.18 Published 1986 Journal Klin. Wochenschr. Section Abstract Doc Link 3643349 Disease Relevance 0.87 Pain Relevance 0.17

The aim of the present study was to compare the changes of serum levels of ELISA-elastase-1, lipase and amylase in acute pancreatic damage following ERCP.

Regulation (changes) of ELISA-elastase-1

2) Confidence 0.11 Published 1999 Journal Z Gastroenterol Section Abstract Doc Link 10494604 Disease Relevance 0.35 Pain Relevance 0.14

In order to investigate modifications of serum levels of elastase 1, immunoreactive trypsin, alpha 1-antitrypsin and alpha 2-macroglobulin in chronic pancreatic disease, and to speculate on the possible relationships among these parameters, the enzymes and inhibitors were assayed in the sera of 33 control subjects, 34 pancreatic cancer, 28 chronic pancreatitis and 36 extra-pancreatic diseases.

Spec (investigate) Regulation (modifications) of elastase 1 associated with pancreatic cancer, pancreatitis and chronic pancreatitis

3) Confidence 0.07 Published 1986 Journal Enzyme Section Abstract Doc Link 2427333 Disease Relevance 0.63 Pain Relevance 0.15

In patients with chronic relapsing pancreatitis, increased P-isoamylase and elastase 1 values were found in similar percentages (about 70%), whereas the percentage for elevated amylase values was lower (52%).

Regulation (values) of elastase 1 associated with pancreatitis

4) Confidence 0.03 Published 1990 Journal J. Clin. Chem. Clin. Biochem. Section Abstract Doc Link 2230667 Disease Relevance 0.71 Pain Relevance 0.13

We compared the diagnostic sensitivities of serum amylase, lipase (assayed enzymatically and immunologically), trypsinogen and elastase-1, the 2-h-timed urine amylase excretion and the ratio of amylase and creatinine clearances in the recognition of acute pancreatitis.

Regulation (sensitivities) of elastase-1 in urine associated with pancreatitis

5) Confidence 0.01 Published 1990 Journal Clin. Chim. Acta Section Abstract Doc Link 2323064 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

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