INT21987

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Context Info
Confidence 0.33
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 30
Total Number 32
Disease Relevance 12.70
Pain Relevance 12.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rorb) cellular_component (Rorb)
Anatomy Link Frequency
spinal cord 2
brain 1
nucleus 1
motor neurons 1
neural 1
Rorb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 198 100.00 Very High Very High Very High
Hippocampus 62 99.90 Very High Very High Very High
Glutamate 61 99.80 Very High Very High Very High
Neuropathic pain 43 99.72 Very High Very High Very High
Spinal cord 152 99.68 Very High Very High Very High
Opioid 12 99.68 Very High Very High Very High
Nucleus accumbens 3 99.68 Very High Very High Very High
Hyperalgesia 28 99.40 Very High Very High Very High
ischemia 194 99.36 Very High Very High Very High
aspirin 8 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 211 100.00 Very High Very High Very High
Neuropathic Pain 70 99.72 Very High Very High Very High
Frailty 4 99.68 Very High Very High Very High
Nociception 94 99.60 Very High Very High Very High
Hyperalgesia 29 99.40 Very High Very High Very High
Cv Unclassified Under Development 115 99.36 Very High Very High Very High
Cv General 4 Under Development 65 98.20 Very High Very High Very High
Headache 10 97.20 Very High Very High Very High
Pneumonia 14 97.12 Very High Very High Very High
Injury 199 96.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested transcription factor induction during opioid hyperalgesia in non-dependent rats could support the induction or consolidation of neural plasticity in nociceptive amygdaloid circuitry previously suggested to function in bi-directional control of pain and expression of pain-related behaviors.
Positive_regulation (induction) of transcription factor in neural associated with nociception, pain, hyperalgesia and opioid
1) Confidence 0.33 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17631915 Disease Relevance 0.85 Pain Relevance 1.67
Transcription factor induction, however, was not detected in multiple brain regions known to respond in parallel with the same extended amygdalar structures when (1) rats are exposed to interoceptive/physical stressors, or (2) naloxone is used to precipitate abstinence in opioid dependent rats.
Positive_regulation (induction) of Transcription factor in brain associated with narcan and opioid
2) Confidence 0.33 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17631915 Disease Relevance 0.64 Pain Relevance 1.56
Recent studies have demonstrated that several transcription factor genes are rapidly activated by neuronal stimulation.
Positive_regulation (activated) of transcription factor in neuronal
3) Confidence 0.17 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2230801 Disease Relevance 0.23 Pain Relevance 0
Stimulation of ICAM expression is mediated by activation of the transcription factor NF-kappaB.
Positive_regulation (activation) of transcription factor
4) Confidence 0.15 Published 1999 Journal Gastroenterology Section Abstract Doc Link 10092308 Disease Relevance 0.43 Pain Relevance 0.26
Recently, it has been shown that aspirin and sodium salicylate inhibit the activation of the transcription factor NF-kappaB.
Positive_regulation (activation) of transcription factor associated with aspirin
5) Confidence 0.14 Published 1996 Journal FEBS Lett. Section Abstract Doc Link 8941724 Disease Relevance 0.28 Pain Relevance 0.51
ONOO(-) generated by the interaction between exogenous administration of O(2)(*-) and endogenous *NO, or provided by direct injection of ONOO(-), activated the transcription factor NF-kappaB in paw tissues, enhancing expression of the inducible but not the constitutive cyclooxygenase enzyme (COX-2 and COX-1, respectively).
Positive_regulation (activated) of transcription factor in paw
6) Confidence 0.11 Published 2008 Journal FASEB J. Section Abstract Doc Link 18497304 Disease Relevance 1.11 Pain Relevance 0.98
Activation of the transcription factor NF-kappaB in the nucleus trigeminalis caudalis in an animal model of migraine.
Positive_regulation (Activation) of transcription factor in nucleus associated with migraine
7) Confidence 0.10 Published 2005 Journal Neurotoxicology Section Title Doc Link 15936821 Disease Relevance 0.36 Pain Relevance 0.37
However, we have previously shown that NK1 receptor-immunoreactive projection neurons belonging to each morphological class are equally likely to up-regulate the transcription factor Fos after noxious chemical stimulation, and that the density of innervation by substance P-containing (nociceptive) afferents is similar for cells of each type [J Neurosci 22 (2002) 4103].
Positive_regulation (up-regulate) of transcription factor in projection neurons associated with nociception, pyramidal cell and substance p
8) Confidence 0.10 Published 2005 Journal Neuroscience Section Abstract Doc Link 15680704 Disease Relevance 0.10 Pain Relevance 0.38
If this mechanism applies to the adult organism, and in particular to the injury response of motor neurons observed in the present case, the down-regulation of a suppressor transcription factor could have the same effect as the up-regulation of a transcription factor enhancer targeting the same genes, i.e. induce transcription.
Positive_regulation (regulation) of transcription factor in motor neurons associated with injury
9) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.25 Pain Relevance 0
The third transcription factor, NF-IL-6, can be activated by a lot of biological signals but contains a highly conserved phosphorylation site for MAPKs [41], which regulates its nuclear translocation in response to growth factors [42].
Positive_regulation (activated) of transcription
10) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.12 Pain Relevance 0.07
The transcription factor DeltaFosB is induced in the nucleus accumbens (NAc) by drugs of abuse.
Positive_regulation (induced) of transcription factor in NAc associated with nucleus accumbens
11) Confidence 0.07 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20438612 Disease Relevance 0.37 Pain Relevance 0.72
Activation of the transcription factor NF-kB was measured using a commercially available ELISA kit (Trans-AM™ NF-kB p65 Transcription Factor Assay Kit, Active Motif, Carlsbad, CA) according to manufacturer's instructions.
Positive_regulation (Activation) of transcription factor
12) Confidence 0.07 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0 Pain Relevance 0.03
These kinases play an important role in the subsequent activation or phosphorylation of the transcription factor, CREB.
Positive_regulation (activation) of transcription factor
13) Confidence 0.06 Published 2005 Journal Mol Pain Section Body Doc Link PMC1224868 Disease Relevance 0 Pain Relevance 0.13
Furthermore, we investigated the activation of the transcription factor NF-?
Spec (investigated) Positive_regulation (activation) of transcription factor
14) Confidence 0.04 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.25 Pain Relevance 0
Cyclic AMP-responsive element binding protein (CREB) is a well-characterized stimulus-induced transcription factor whose activation requires phosphorylation of the Serine-133 residue.
Positive_regulation (induced) of transcription factor
15) Confidence 0.04 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1224868 Disease Relevance 0.16 Pain Relevance 0.19
Western blot analyses demonstrated that in the spinal cord, CFA also increased levels of phosphorylated cAMP response element-binding protein (CREB), while in the hippocampus the activation of this transcription factor was significantly reduced, further suggesting that tissue specific transcription of either NK-1 or BDNF genes may be partially regulated by common intracellular transduction mechanisms mediated through activation of CREB.
Positive_regulation (activation) of transcription factor in spinal cord associated with hippocampus and spinal cord
16) Confidence 0.04 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2174921 Disease Relevance 0.67 Pain Relevance 0.72
A role for reactive oxygen species in Ang II-mediated transcription factor activation has been established.
Positive_regulation (activation) of transcription factor
17) Confidence 0.03 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 0.63 Pain Relevance 0.10
These cytokines exert their actions, at least partially, through the activation of the transcription factor, nuclear factor kappaB (NF-kappaB).
Positive_regulation (activation) of transcription factor associated with cytokine
18) Confidence 0.03 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.81 Pain Relevance 0.79
We next examined whether EDC could regulate activation of the transcription factor, CREB, and its transcriptional target BDNF in the hippocampal CA1 region after GCI.
Positive_regulation (activation) of transcription factor associated with ischemia and bdmf
19) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.53 Pain Relevance 0.47
Among them, we described that cAMP response element binding protein (CREB), a pleiotropic transcription factor that has been involved both in cell proliferation and survival [15], is phosphorylated and therefore activated, upon glutamate stimulation in these differentiated cells [13].
Positive_regulation (activated) of transcription factor associated with glutamate
20) Confidence 0.01 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2666774 Disease Relevance 0.06 Pain Relevance 0.33

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