INT219980

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.17 Pain Relevance 0.96

cytosol (THRA) nucleoplasm (THRA) nucleus (THRA) transcription factor binding (THRA)

Anatomy Link Frequency thyroid 1 neurons 1 ear skin 1 THRA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 38 99.96 Acupuncture 26 94.06 Calcium channel 14 82.72 analgesia 3 74.92 narcan 1 70.16 antagonist 1 69.80 opiate 1 69.36 conotoxin 2 59.76 drug abuse 2 59.64 withdrawal 2 58.24

Disease Link Frequency Relevance Heat Cancer 14 98.80 Parathyroid Cancer 1 94.44 Carcinoid 1 87.20 Thyroid Hormone Resistance Syndrome 3 79.84 Hypothyroidism 2 78.60 Disease 27 59.96 Drug Dependence 2 59.64 Alcohol Addiction 1 58.24 Obesity 4 56.76 Functional Bowel Disorder 1 56.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aberrant alternative splicing of thyroid hormone-receptor ?

Positive_regulation (splicing) of thyroid hormone-receptor in thyroid

1) Confidence 0.49 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.78 Pain Relevance 0

Auricolotherapy is a treatment diffusing in all over the world, and its patterns follow the principles of Chinese acupuncture, revised and updated, with Chinese maps of the ear; the principles of Paul Nogier and also the principles of reflexology basing on somatotopic maps that do not recognize energetic-based stimulation, while just the evocation of a reflex stimulating precise areas of the ear; moreover are used for stimulation of ear skin many different tools: finger acupressure, laser, electricity, different types of needles, magnetic balls, seeds.

Positive_regulation (stimulation) of ear in ear skin associated with acupuncture

2) Confidence 0.15 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2206232 Disease Relevance 0.40 Pain Relevance 0.63

Figure 2a shows a BLAST representation of EAR element sequence conservation in the human genome.

Positive_regulation (conservation) of EAR

3) Confidence 0.07 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0

-selective agonists, ERB-041, DPN and MF101 increased [Ca2+]i oscillations, amplitudes and synchronizations in neurons from mES cells, whereas ER?

Positive_regulation (increased) of ERB-041 in neurons associated with agonist

4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.33

General Comments

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