INT220178

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.98
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl13) extracellular space (Cxcl13) extracellular region (Cxcl13)
cell-cell signaling (Cxcl13)
Anatomy Link Frequency
immune cell 1
Cxcl13 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 26 100.00 Very High Very High Very High
rheumatoid arthritis 408 97.40 Very High Very High Very High
Chronic pancreatitis 37 97.16 Very High Very High Very High
Inflammation 121 97.00 Very High Very High Very High
cytokine 28 95.12 Very High Very High Very High
Inflammatory response 14 93.24 High High
Central nervous system 22 78.04 Quite High
tolerance 9 57.44 Quite High
corticosteroid 1 27.84 Quite Low
Arthritis 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 5 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 30 99.44 Very High Very High Very High
Infection 116 99.12 Very High Very High Very High
Rheumatoid Arthritis 409 97.40 Very High Very High Very High
Pancreatitis 54 97.16 Very High Very High Very High
Togavirus Infection 150 97.04 Very High Very High Very High
INFLAMMATION 138 97.00 Very High Very High Very High
Viral Meningitis 8 89.12 High High
Apoptosis 35 83.52 Quite High
Pressure And Volume Under Development 6 82.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Cxcl13 in immune cell associated with chemokine, injury and infection
1) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.52 Pain Relevance 0.27
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Cxcl13 associated with chemokine
2) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.90 Pain Relevance 0.63
Median CXCL13-mRNA levels in AIPC were also significantly higher than in the other groups, with a 21-fold increase compared to CP (p?
Positive_regulation (Median) of CXCL13 associated with chronic pancreatitis
3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440515 Disease Relevance 1.07 Pain Relevance 0.49
As synovial tissues containing sites of ectopic lymphoneogenesis have been demonstrated to be closely associated with increased expression levels of CXCL13 and LT?
Positive_regulation (increased) of CXCL13
4) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.30 Pain Relevance 0.15
Expression of AID Is Associated with the Up-regulation of CXCL13 and LT?
Positive_regulation (regulation) of CXCL13
5) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.38 Pain Relevance 0.19
As shown in Figure 2, AID mRNA+ tissues displayed significantly higher levels of CXCL13 and LT?
Positive_regulation (levels) of CXCL13
6) Confidence 0.23 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.21 Pain Relevance 0.10
B also plays an important role in lymphoid organogenesis through the induction of the chemokines CXC12, CXCL13, CCL21 and CCL19 [44-48].
Positive_regulation (induction) of CXCL13 associated with chemokine
7) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.61 Pain Relevance 0.39

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