INT220210

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL10A1)
Anatomy Link Frequency
chondrocyte 2
COL10A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 18 99.80 Very High Very High Very High
Osteoarthritis 39 98.44 Very High Very High Very High
cytokine 10 90.56 High High
COX2 1 71.84 Quite High
Inflammation 8 27.04 Quite Low
Arthritis 2 23.36 Low Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 22 100.00 Very High Very High Very High
Osteoarthritis 51 98.44 Very High Very High Very High
Disease 4 47.20 Quite Low
INFLAMMATION 8 27.04 Quite Low
Arthritis 5 23.36 Low Low
Cancer 2 22.24 Low Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In comparison with controls, OA explants from five patients cultured in the presence of 10 pg/ml PGE2 showed decreased expression of the genes related to chondrocyte hypertrophy, namely those encoding COL10A1 and MMP-13 (Figure 3).
Negative_regulation (decreased) of Gene_expression (expression) of COL10A1 in chondrocyte associated with hypertrophy, metalloproteinase and osteoarthritis
1) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.41

General Comments

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