INT220366

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2007
Negated 2
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.61
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cish)
Cish (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 260 99.22 Very High Very High Very High
Inflammation 10 78.48 Quite High
ischemia 5 72.48 Quite High
analgesia 10 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Buprenorphine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 185 99.84 Very High Very High Very High
INFLAMMATION 10 78.48 Quite High
Peritonitis 5 77.76 Quite High
Ileus 10 74.16 Quite High
Cv General 4 Under Development 5 73.36 Quite High
Critical Illness 45 5.00 Very Low Very Low Very Low
Body Weight 35 5.00 Very Low Very Low Very Low
Starvation 25 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Necrosis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As seen in the prior study, however, SOCS-2 expression was not affected by sepsis [14].
Neg (not) Regulation (affected) of Gene_expression (expression) of SOCS associated with sepsis
1) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.47 Pain Relevance 0.13
While differences in cytokine levels were observed, any mechanistic influence of these on SOCS expression cannot be determined from the present study.
Regulation (influence) of Gene_expression (expression) of SOCS associated with cytokine
2) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.63 Pain Relevance 0.13
These differences in SOCS expression appeared independent of the induction of mRNA of the GHR or of IGF-I.
Neg (independent) Spec (appeared) Regulation (independent) of Gene_expression (expression) of SOCS
3) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.40 Pain Relevance 0.14
In light of the previous study that demonstrated an effect of PN on CIS expression [14], we were particularly interested in the possibility that nutrition, and possibly the route of feeding, might influence SOCS expression and thus GH resistance.
Regulation (effect) of Gene_expression (expression) of CIS
4) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.58 Pain Relevance 0.08
In light of the previous study that demonstrated an effect of PN on CIS expression [14], we were particularly interested in the possibility that nutrition, and possibly the route of feeding, might influence SOCS expression and thus GH resistance.
Spec (might) Regulation (influence) of Gene_expression (expression) of SOCS
5) Confidence 0.12 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.53 Pain Relevance 0.10

General Comments

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