INT220504

Context Info Confidence 0.39 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 11 Total Number 11 Disease Relevance 6.26 Pain Relevance 0.43

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1) endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)

Anatomy Link Frequency fibroblasts 4 tube 2 colon 2 lung 2 Cav1 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 12 99.56 fibrosis 56 95.76 antagonist 20 73.40 agonist 45 57.80 Kinase C 2 50.36 Inflammatory mediators 8 42.88 cytokine 15 27.40 Inflammation 67 24.96 Bile 2 14.20 cINOD 30 5.00

Disease Link Frequency Relevance Heat Hypokalemic Periodic Paralysis 29 99.70 Cancer 489 99.00 Adenocarcinoma 10 98.88 Death 27 96.40 Pulmonary Fibrosis 29 95.96 Adenoma 6 95.20 Carcinoma 4 94.68 Stress 67 93.28 Fibrosis 44 92.56 Breast Cancer 240 90.40

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Disruption of the maxi-K channel's association with caveolin-1 in mouse fibroblasts leads to channel mislocalization

Positive_regulation (leads) of Gene_expression (Disruption) of caveolin-1 in fibroblasts

1) Confidence 0.39 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0

The discovery of single missense CACNA1S mutations in humans with HPP-1 which still allow expression of a full-length Cav1.1 ?

Positive_regulation (allow) of Gene_expression (expression) of Cav1 associated with hypokalemic periodic paralysis

2) Confidence 0.37 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 1.06 Pain Relevance 0

In contrast, the Ltk- mouse fibroblasts used in our study expressed endogenous cav-1, thus providing a more physiological environment for the study of caveolin-maxi-K interactions.

Positive_regulation (providing) of Gene_expression (expressed) of cav-1 in fibroblasts

3) Confidence 0.36 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.09 Pain Relevance 0

While, the expression of caveolin-1 is elevated in a majority of the colon adenocarcinomas, the expression of caveolin-2 is undetectable in either normal colonocytes, adenomas, or carcinomas (Fine et al. 2001; Patlolla et al. 2004).

Positive_regulation (elevated) of Gene_expression (expression) of caveolin-1 in colon associated with adenoma, adenocarcinoma and carcinoma

4) Confidence 0.22 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.39 Pain Relevance 0

For example, overexpression of caveolin-1 significantly enhances endothelial cell differentiation into tube-like structures and downregulation of caveolin-1 protein levels using antisense oligonucleotides reduced the ability of the endothelial cells to form an organized network (Liu et al. 2002; Griffoni et al. 2000).

Positive_regulation (overexpression) of Gene_expression (overexpression) of caveolin-1 in tube

5) Confidence 0.21 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.73 Pain Relevance 0.03

Tumor growth inhibition with CDIM9 in vitro and in vivo correlated with increased p27 and caveolin-1 protein expression.

Positive_regulation (increased) of Gene_expression (expression) of caveolin-1 protein associated with cancer

6) Confidence 0.17 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.84 Pain Relevance 0.03

activation led to further increases in caveolin-1 expression and cell growth arrest.

Positive_regulation (increases) of Gene_expression (expression) of caveolin-1

7) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.92 Pain Relevance 0.07

As shown in Figure 6c, a dramatic increase in caveolin-1 expression (7.2-fold) was detected in tumors from CDIM9 treated mice.

Positive_regulation (increase) of Gene_expression (expression) of caveolin-1 associated with cancer

8) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.30 Pain Relevance 0

The suppressive effects of ozone on Cav-1 expression were not observed in TNFR1?

Neg (not) Positive_regulation (observed) of Gene_expression (expression) of Cav-1

9) Confidence 0.15 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.07 Pain Relevance 0

The expression of caveolin-1 was also affected by CDIM9 treatment; in MDA-MB231 cells caveolin-1 expression was upregulated 1.7-fold, 2.4-fold, and 3.4-fold after treatment with 5, 10, and 20 ?

Positive_regulation (upregulated) of Gene_expression (expression) of caveolin-1

10) Confidence 0.15 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.21 Pain Relevance 0.03

We previously demonstrated that those cells of abnormal re-epithelialization were characterized by diminishment of caveolin-1 and the increased expression of matrix metalloproteinases (MMPs) and extracellular matrix metalloproteinase inducer (EMMPRIN) in lung fibrosis [17,18].

Positive_regulation (increased) of Gene_expression (expression) of caveolin-1 in lung associated with fibrosis, metalloproteinase and pulmonary fibrosis

11) Confidence 0.11 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.64 Pain Relevance 0.29

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