INT22081

Context Info Confidence 0.23 First Reported 1990 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 4.11 Pain Relevance 0.95

signal transduction (Ceacam1) cell adhesion (Ceacam1) plasma membrane (Ceacam1)

Anatomy Link Frequency blood 1 urine 1 Ceacam1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat cINOD 1 99.84 Pain 15 96.64 corticosteroid 46 92.00 analgesia 1 88.04 headache 2 87.00 tramadol 1 85.76 isoflurane 1 83.84 adenocard 4 42.08 agonist 6 23.16 Inflammation 8 11.68

Disease Link Frequency Relevance Heat Hypercalcemia 8 100.00 INFLAMMATION 10 99.72 Multiple Myeloma 8 98.20 Disease 29 97.28 Pain 16 96.64 Osteoporosis 66 95.68 Osteogenesis Imperfecta 27 89.76 Hypocalcemia 3 89.28 Diarrhoea 1 87.56 Headache 2 87.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The usual nonsteroid anti-inflammatory drugs had no effect on blood osteocalcin level.

Neg (no) Regulation (effect) of osteocalcin in blood associated with inflammation and cinod

1) Confidence 0.23 Published 1990 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 2247770 Disease Relevance 0.18 Pain Relevance 0.10

There was no statistically significant difference in cortisol, osteocalcin, insulin and glucose levels in both groups, when compared to the control levels.

Neg (no) Regulation (difference) of osteocalcin

2) Confidence 0.08 Published 2004 Journal Int. J. Clin. Pract. Section Abstract Doc Link 15587771 Disease Relevance 0.45 Pain Relevance 0.22

Drug design for effects on purinergic responses has targeted the P2X [41] and P2Y [9] classes of receptors as well as the ecto-NTPase activities [16].

Regulation (targeted) of ecto-NTPase

3) Confidence 0.08 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0

The effect of pamidronate on markers of bone resorption [cross-linked N-telopeptides of type I collagen (NTx)], markers of bone formation [serum alkaline phosphatase (BAP) and osteocalcin (OSC)], interleukin-6 (IL-6), beta2-microglobulin, CRP, paraprotein and disease-related pain and skeletal events has been evaluated in 62 newly diagnosed patients with MM.

Regulation (effect) of osteocalcin associated with pain, hypercalcemia, multiple myeloma and disease

4) Confidence 0.02 Published 2000 Journal Eur. J. Haematol. Section Abstract Doc Link 11092464 Disease Relevance 0.83 Pain Relevance 0.10

The effect of treatment on serum osteocalcin was also significant 2.3 ng/ml in budesonide group compared to 0.6 ng/ml in prednisolone (P<0.05).

Regulation (effect) of osteocalcin

5) Confidence 0.01 Published 2010 Journal Lung India : Official Organ of Indian Chest Society Section Body Doc Link PMC2988175 Disease Relevance 0.42 Pain Relevance 0.12

No significant changes were observed in serum alkaline phosphatase, serum osteocalcin, urine hydroxyproline, and urine pyridinoline or deoxypyridinoline.

Neg (No) Regulation (changes) of serum osteocalcin in urine

6) Confidence 0.01 Published 1994 Journal Calcif. Tissue Int. Section Abstract Doc Link 8118746 Disease Relevance 0.55 Pain Relevance 0.17

The biochemical parameters including calcium, phosphorus, alkaline phosphatase, PTH, and osteocalcin levels did not altered significantly in this study.

Neg (not) Regulation (altered) of osteocalcin

7) Confidence 0.01 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693583 Disease Relevance 0.81 Pain Relevance 0

There was a significant change in the levels of osteocalcin and bone alkaline phosphatase (BAP) and also a significant decrease in the number of painful sites (bone pain) experienced by the patients.60,61

Regulation (change) of osteocalcin associated with pain

8) Confidence 0.01 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915556 Disease Relevance 0.87 Pain Relevance 0.24

General Comments

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